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Carnovas HZ 5/12.5
Beximco Pharmaceuticals Ltd.
Generic: Nebivolol + Hydrochlorothiazide
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Carnovas HZ 5/12.5. Please consult your doctor.
CONSULT YOUR DOCTOR
Carnovas HZ 5/12.5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Carnovas HZ 5/12.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Carnovas HZ 5/12.5 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Carnovas HZ 5/12.5 should be used with caution in patients with severe kidney disease. Dose adjustment of Carnovas HZ 5/12.5 may be needed. Please consult your doctor.
Use of Carnovas HZ 5/12.5 is not recommended in patients with severe kidney disease.
CAUTION
Carnovas HZ 5/12.5 should be used with caution in patients with liver disease. Dose adjustment of Carnovas HZ 5/12.5 may be needed. Please consult your doctor.
Medicine Overview of Carnovas HZ 5/12.5mg/12.5mg Tablet
Introduction
Carnovas HZ 5/12.5 is a combination medicine used for treating hypertension (high blood pressure). By lowering the blood pressure, it helps in preventing future heart attack and stroke. Carnovas HZ 5/12.5 should be taken with or without food preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating...
... Show moreUses of Carnovas HZ 5/12.5
- Hypertension (high blood pressure)
Side effects of Carnovas HZ 5/12.5
Common
- Nausea
- Constipation
- Diarrhea
- Fatigue
- Dizziness
- Headache
- Increased blood uric acid
- Decreased potassium level in blood
- Glucose intolerance
- Altered blood lipid level
- Breathlessness
- Swelling of hands
- Feet swelling
- Paresthesia (tingling or pricking sensation)
- Decreased magnesium level in blood
- Increased calcium level in blood
How to use Carnovas HZ 5/12.5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Carnovas HZ 5/12.5 may be taken with or without food, but it is better to take it at a fixed time.
How Carnovas HZ 5/12.5 works
Carnovas HZ 5/12.5 is a combination of two blood-pressure lowering medicines: Nebivolol and Hydrochlorothiazide. Nebivolol is a beta blocker which works specifically on the heart to reduce heart rate and make the heart more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- It is a combination of two blood pressure lowering medications used for the treatment of high blood pressure.
- It can be taken with or without food.
- Do not stop taking Carnovas HZ 5/12.5 suddenly as it can cause your blood pressure to rise suddenly thereby increasing the risk of heart attack and stroke.
- It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position.
- It can hide symptoms of low blood sugar if you're diabetic. Monitor your blood sugar levels regularly.
- Carnovas HZ 5/12.5 may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
Brief Description
Indication
Hypertension
Adult Dose
Oral
Hypertension
Adult: Per tablet contains nebivolol 5 mg and hydrochlorothiazide 12.5 mg: 1 tablet once daily.
Contraindication
Hypersensitivity, liver impairment, anuria, sulphonamide allergy. Pregnancy, lactation.
Mode of Action
Nebivolol exerts its actions by exhibiting a high selectivity for beta-1 adrenergic receptors and also by reducing the peripheral vascular resistance by modulating nitrous oxide release.
Hydrochlorothiazide inhibits the reabsorption of Na and chloride at the beginning of distal convoluted tubule. It causes natriuretic effect mainly by decreasing Na and chloride reabsorption in the cortical segment of the ascending limb of the Loop of Henle by inhibition of a specific Na+Cl- co-transporter.
Precaution
History of allergies, psoriasis, hyperthyroidism, peripheral arterial disease, diabetes, existing electrolyte disturbances, oedema, renal impairment, hyperlipidemia,hyperuricaemia. Elderly.
Side Effect
Nebivolol - Headache, fatigue, parasthesias, dizziness.
Hydrochlorothiazide - Hypotension including orthostatic hypotension, pancreatitis, intrahepatic cholestatic jaundice, diarrhoea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, thrombocytopenia, photosensitivity, fever, urticaria, rash, purpura, hyperglycemia, glycosuria, hyperuricemia, restlessness, impotence.
Potentially Fatal: Seizures, may unmask diabetes mellitus. Hyponatraemia and idiosyncratic, hypersensitivity reactions.
Interaction
Symptomatic hyponatraemia when combined with carbamazepine. Predisposes to allopurinol sensitivity reactions and impaired renal function. Potentiates hypotensive effect of beta blockers and ACE inhibitors; these also reduce diuretic-induced hypokalaemia.
Potentially Fatal: Enhance neuromuscular blocking action of competitive muscle relaxants. Cross-allergy with sulphonamides and sulphonylurea hypoglycaemics with resultant acute interstitial nephritis and vasculitis. Potentiates bone-marrow suppression caused by anticancer drugs. Potentiates aminoglycoside nephrotoxicity. Impaired control of diabetes by oral hypoglycaemic agents. May precipitate digitalis toxicity and lithium toxicity. Increased risk of hypokalaemia with corticosteroids. Prolongs paralysis caused by tubocurarine.
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