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Safety Advices
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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Carbotin. Please consult your doctor.
CONSULT YOUR DOCTOR
Carbotin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Carbotin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Carbotin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Carbotin should be used with caution in patients with kidney disease. Dose adjustment of Carbotin may be needed. Please consult your doctor.
Use of Carbotin is not recommended in patients with severe kidney disease. Regular monitoring of kidney function tests may be advised while you are taking this medicine.
SAFE IF PRESCRIBED
Carbotin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Carbotin may not be needed in these patients. Please consult your doctor.
Medicine Overview of Carbotin 450mg/45ml Injection
Introduction
Carbotin is used in the treatment of ovarian cancer and small cell lung cancer. It shows its working by stopping or slowing down the growth of cancer cells. Carbotin is given as an injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side...
... Show moreUses of Carbotin
- Ovarian cancer
- Small cell lung cancer
Side effects of Carbotin
Common
- Nausea
- Vomiting
- Anemia (low number of red blood cells)
- Fatigue
- Low blood platelets
- Increased liver enzymes
- Decreased white blood cell count (neutrophils)
- Stomatitis (Inflammation of the mouth)
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Diarrhea
How to use Carbotin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Carbotin works
Carbotin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.
What if you forget to take Carbotin?
If you miss a dose of Carbotin, please consult your doctor.
Quick Tips
- It is given as an injection into the veins under the supervision of a doctor.
Brief Description
Indication
Ovarian carcinoma, Lung cancer
Administration
IV Preparation Single-dose lyophilized powder (reconstitution require) Reconstitute powder with sterile water for injection, D5W, or 0.9% NaCl to yield a final concentration of 10 mg/mL Can be further diluted to concentrations as low as 0.5 mg/mL with D5W or 0.9% NaCl Multidose premixed injectable solution Available as a 10 mg/mL aqueous solution Can be further diluted to concentrations as low as 0.5 mg/mL with D5W or 0.9% NaCl IV Administration Administer IV over 15 min or continuous IV infusion over 24 hr May also be administered intraperitoneally When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered...
... Show moreAdult Dose
Intravenous
Small cell lung cancer; Advanced ovarian carcinoma
Adult: IV As single agent in treatment-naive patients: 400 mg/m2;
As single agent in previously treated patients: 360 mg/m2; W/ cyclophosphamide in treatment-naive patients: 300 mg/m2.
Doses to be given not more frequently than every 4 wk. Adjust subsequent doses based on nadir of WBC and platelet counts.
Hepatic Impairment
Dose adjustment may not be necessary; not studied
Child Dose
Solid tumor
300-600 mg/m² IV q4Weeks
Sarcoma (bone/soft tissue)
400 mg/m²/day for 2 days every 21 days
Brain tumor
175 mg/m² qWeek x 4 weeks with a 2 weeks recovery period between courses
Bone marrow transplant preparative regimen
500 mg/m²/day x 3 days
Retinoblastoma
1-2 mL subconjunctival injection of 10 mg/mL solution per dose
Renal Dose
Renal impairment:
CrCl (ml/min)
>40 Recommended dose: 400 mg/m2.
20-39 Recommended dose: 250 mg/m2.
Contraindication
Previous allergy; pregnancy, lactation; allergy to other platinum compounds; severe bone marrow depression; significant bleeding, aluminium containing needles and IV sets.
Mode of Action
Carboplatin is an alkylating agent which binds covalently to DNA. It modifies the cell cycle by interfering with DNA structure and function.
Precaution
Neonates; diminished renal function; neurotoxicity; liver function impairment.
Lactation: not known if excreted in breast milk; do not nurse
Side Effect
>10%
Leukopenia (26-97%),Neutropenia (21-96%),Nausea (81-93%),Vomiting (81-93%),Anemia (14-90%),Magnesium loss (43-61%),Thrombocytopenia (33-66%),Alopecia (2-49%),Asthenia (11-41%),Elevated alkaline phosphatase (29-37%),Central neurotoxicity (5-26%),Elevated AST (19-20%),Peripheral neuropathy (6-15%)
1-10%
Immune hypersensitivity reaction (2-9.2%),Elevated bilirubin (5%)
Frequency Not Defined
Visual disturbance (rare)
Potentially Fatal: Bone marrow suppression and anaphylactic reactions.
Pregnancy Category Note
Pregnancy Category: D
Lactation: not known if excreted in breast milk; do not nurse
Interaction
Increased risk of ototoxicity when used with aminoglycosides.
