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Isentin 5
Healthcare Pharmaceuticals Ltd.
Generic: Linagliptin
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Isentin 5.
SAFE IF PRESCRIBED
Isentin 5 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Isentin 5 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Isentin 5 is safe to use in patients with kidney disease. No dose adjustment of Isentin 5 is recommended.
SAFE IF PRESCRIBED
Isentin 5 is safe to use in patients with liver disease. No dose adjustment of Isentin 5 is recommended.
Medicine Overview of Isentin 5mg Tablet
Introduction
Isentin 5 is a medicine used to treat type 2 diabetes mellitus. It is used together with a healthy diet and regular exercise to control blood sugar levels. This helps to prevent serious complications of diabetes like kidney damage and blindness. Isentin 5 is normally prescribed when diet and exercise alone or other medicines do not prove sufficient to control your blood sugar level. Your doctor may prescribe it alone or along with other diabetes medicines. It can be taken with or without food. The dose will depend on your condition, and blood sugar levels. Therefore, you should use it...
... Show moreUses of Isentin 5
- Type 2 diabetes mellitus
Side effects of Isentin 5
Common
- Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
- Headache
- Nasopharyngitis (inflammation of the throat and nasal passages)
- Cough
- Allergic reaction
How to use Isentin 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isentin 5 may be taken with or without food, but it is better to take it at a fixed time.
How Isentin 5 works
Isentin 5 is an antidiabetic medication. It works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and postmeal sugar levels.
Quick Tips
- Isentin 5 should be taken at the same time every day since this helps you remember to take it.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Be careful while driving or operating machinery until you know how Isentin 5 affects you.
- Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea and/or vomiting.
Brief Description
Indication
Type 2 Diabetes Mellitus
Administration
May administer with or without food
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: 5 mg once daily.
Indicated for adults with diabetes mellitus type II along with diet and exercise to lower blood sugar; may be used as monotherapy or in combination with other common antidiabetic medications including metformin, sulfonylurea, pioglitazone, or insulin.
Elderly: No dose adjustment is necessary based on age.
Hepatic or renal impairment: No dosage adjustment required.
Child Dose
Safety and efficacy not established
Renal Dose
Renal Impairment: No dose adjustment.
Contraindication
Patients with a history of a hypersensitivity reaction to linagliptin, such as urticaria, angioedema, or bronchial hyperreactivity. Type 1 DM. Treatment of diabetic ketoacidosis.
Mode of Action
Dipeptidyl peptidase 4 (DPP-4) inhibitor; increases and prolongs incretin hormone activity which is inactivated by DPP-4 enzyme.
Incretins regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic beta cells and reducing glucagon secretion from pancreatic alpha cells .
Precaution
Concomitant use w/ sulphonylureas which are known to cause hypoglycemia; dose reduction of sulphonylureas may be considered. May affect ability to drive or operate machinery. Childn. Elderly >75 yr. Pregnancy & lactation.
Lactation: Unknown whether distributed in breast milk; caution advised
Side Effect
1-10%
Nasopharyngitis (4.3%),Hyperlipidemia (2.8%; with pioglitazone),Cough (2.4%; with metformin and sulfonylurea),Hypertriglyceridemia (2.4%; with sulfonylurea),Weight gain (2.3%; with pioglitazone),
Hypoglycemia 7.6% overall incidence, 22.9% incidence compared with placebo plus metformin and a sulfonylurea
Incidence similar to placebo with monotherapy or combined with metformin or pioglitazone
Interaction
Increased risk of hypoglycaemia when used w/ an insulin secretagogue (e.g. sulfonylurea) or insulin. Plasma concentration of linagliptin may be decreased by strong inducers of P-glycoprotein (e.g. rifampicin) and may be increased by strong P-glycoprotein inhibitors (e.g. ritonavir).
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