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Tplase 50
Healthcare Pharmaceuticals Ltd.
Generic: Tenecteplase
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Tplase 50. Please consult your doctor.
CONSULT YOUR DOCTOR
Tplase 50 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CAUTION
Tplase 50 should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
NOT RELEVANT
Not relevant, as Tplase 50 is intended for use in hospitalised patients.
CONSULT YOUR DOCTOR
There is limited information available on the use of Tplase 50 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Tplase 50 in patients with liver disease. Please consult your doctor.
Medicine Overview of Tplase 50 5ml/50mg Injection
Introduction
Tplase 50 belongs to a group of medicines called thrombolytic agents. It is used in the emergency treatment of heart attack. It helps to dissolve blood clots that have formed in the blood vessels of the heart. Tplase 50 is an injectable drug, given directly into a vein and it is given by a doctor as soon as possible after the first signs of a heart attack. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely. You may be given another medicine to stop blood clotting at the same time or after the treatment. This...
... Show moreUses of Tplase 50
- Heart attack
Side effects of Tplase 50
Common
- Injection site bleeding
- Nosebleeds
- Blood in stool
- Blood in urine
- Gastrointestinal bleeding
How to use Tplase 50
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Tplase 50 works
Tplase 50 is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.
Quick Tips
- Tplase 50 is used to treat myocardial infarctions (heart attacks) as soon as possible (usually within 12 hours) after the onset of symptoms.
- It is given as an injection into the vein under the supervision of a doctor.
- It may increase your risk of bleeding. Inform your doctor immediately if you notice bleeding at the injection site, nose bleed, and blood in urine.
- Continue with your diet and exercise along with previously prescribed medications for heart attack.
Brief Description
Indication
Acute myocardial infarction
Administration
IV Preparation
Add 10 mL SWI to a 50 mg vial using TwinPak® device directing stream of diluent into powder. If foaming (usually slight) occurs, leave vial undisturbed for several minutes to allow dissipation of any large bubbles. Gently swirl (do not shake) until contents are completely dissolved.
Adult Dose
Intravenous
Acute myocardial infarction
Adult: 30-50 mg as a single bolus dose over 5-10 sec as soon as possible after the onset of symptoms. The dose is based on body weight. Max: 50mg.
Administer ASAP (within 30 minutes) after onset of acute MI
30-50 mg IV bolus over 5 sec once (based on weight)
90 kg: 50 mg
Contraindication
Patients at risk of cerebral bleeding including severe hypertension, history of stroke, intracranial or intraspinal surgery or trauma within 2 mth, arteriovenous malformation or aneurysm, cerebral neoplasm. Haemorrhage or known bleeding diathesis.
Mode of Action
Tenecteplase is a biosynthetic form of the enzyme human tissue-type plasminogen activator (t-PA). It is a fibrin-specific thrombolytic, converts plasminogen to plasmin, a proteolytic enzyme that has fibrinolytic effects.
Precaution
Patients with increased risk of bleeding. Recent history of GI or genitourinary bleed, recent major surgery, previous puncture of noncompressible vessels, hypertension (>180/110 mm Hg), high risk of left heart thrombus, acute pericarditis, subacute bacterial endocarditis, coagulation defects, invasive procedures, haemorrhagic ophthalmic conditions. Elderly, pregnancy and lactation. Severe hepatic impairment.
Lactation: not known whether drug crosses into breast milk, nursing not a priority in AMI
Side Effect
>10%
Minor bleeding (22%)
Frequency Not Defined
Reperfusion arrhythmias
MI
Fever
Nausea
Vomiting
Cholesterol embolization
Allergic reaction
Interaction
Increased risk of haemorrhage with heparin, oral anticoagulants, antiplatelet drugs and other drugs that can affect platelet function.
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