12-24 Hours
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Citofer 210
Incepta Pharmaceuticals Ltd.
Generic: Ferric Citrate
Medicine Overview of Citofer 210mg tablet
বাংলা
English
Brief Description
Indications
Ferric Citrate is indicated in-
The control of serum phosphorus levels in adult patients with chronic kidney disease on dialysis.
The treatment of iron deficiency anemia in adult patients with chronic kidney disease not on dialysis.
Pharmacology
Ferric iron binds dietary phosphate in the Gl tract and precipitates as ferric phosphate. This compound is insoluble and is excreted in the stool. By binding phosphate in the Gl tract and decreasing absorption, ferric iron lowers the phosphate concentration in the serum. Ferric iron is reduced from the ferric to the ferrous form by ferric reductase in the Gl tract. After transport through the enterocytes into the blood, oxidized ferric iron circulates bound to the plasma protein transferrin, and can be incorporated into hemoglobin.
Dosage & Administration
Hyperphosphatemia in Chronic Kidney Disease on Dialysis: Starting dose is 2 tablets orally 3 times per day with meals Adjust dose by 1 to 2 tablets as needed to maintain serum phosphorus at target levels, up to a maximum of 12 tablets daily. Dose can be titrated at 1-week or longer intervals. Iron Deficiency Anemia in Chronic Kidney Disease not on Dialysis: Starting dose is 1 tablet orally 3 times per day with meals Adjust dose as needed to achieve and maintain hemoglobin goal, up to a maximum of 12 tablets daily or as directed by the physician. Use in...
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Oral drugs such as Doxycycline & Ciprofloxacin have to be separated from Ferric Citrate.
Contraindications
Ferric Citrate is contraindicated in patients with iron overload syndrome (Hemochromatosis).
Side Effects
Most common adverse reactions are discolored feces, diarrhoea, constipation, nausea, vomiting, cough, abdominal pain and hyperkalemia.
Pregnancy & Lactation
There are no available data on Ferric Citrate use in pregnant women & Lactating mother.
Precautions & Warnings
Iron absorption from Phoscon may lead to excessive elevations in iron stores. May increase in serum ferritin and transferrin saturation (TSAT) levels. Patients may require a reduction in dose or discontinuation of intravenous iron.Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years of age. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center in hospital immediately.
Overdose Effects
No data are available regarding overdose of Ferric Citrate in patients. In patients with Chronic Kidney Disease, the maximum dose studied was 2,520 mg ferric iron per day.
Therapeutic Class
Oral Iron preparations
Storage Conditions
Store below 30°C, away from light and in a dry place. Keep out of the reach of children.
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