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Corofree 200
Aristopharma Limited
Generic: Hydroxychloroquine Sulphate
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Corofree 200. Please consult your doctor.
CONSULT YOUR DOCTOR
Corofree 200 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Corofree 200 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Corofree 200 may cause side effects which could affect your ability to drive.
You may get eye problems while taking this medicine. This may affect your ability to drive.
CAUTION
Corofree 200 should be used with caution in patients with kidney disease. Dose adjustment of Corofree 200 may be needed. Please consult your doctor.
This medicine can affect your eyes. Regular eye check up is recommended while you are taking this medicine.
CAUTION
Corofree 200 should be used with caution in patients with liver disease. Dose adjustment of Corofree 200 may be needed. Please consult your doctor.
Medicine Overview of Corofree 200mg Tablet
Introduction
Corofree 200 is used in the treatment of autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus. It slows down the progression of the disease and provides relief from pain, swelling, and redness. Corofree 200 should be taken with food. This will prevent you from getting an upset stomach upset. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Using this medicine may cause some common side effects such as blurred vision,...
... Show moreUses of Corofree 200
- Rheumatoid arthritis
- Systemic lupus erythematosus (SLE)
Side effects of Corofree 200
Common
- Blurred vision
- Abdominal pain
- Diarrhea
- Feeling sick
- Headache
- Loss of appetite
- Mood changes
How to use Corofree 200
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Corofree 200 is to be taken with food.
How Corofree 200 works
Corofree 200 is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system that causes inflammation (swelling) and pain in the joints. This slows the progression of the underlying disease.
What if you forget to take Corofree 200?
If you miss a dose of Corofree 200, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed HCQS 200 Tablet for the treatment of autoimmune conditions such as rheumatoid arthritis or systemic lupus erythematosus.
- Take it with food to avoid an upset stomach.
- It can take 8-12 weeks for HCQS 200 Tablet to work. Keep taking it as prescribed.
- Do not take medicines that neutralise stomach acids (antacids) four hours before and after taking HCQS 200 Tablet as they can stop the medicine from being absorbed properly from your gut.
- Have regular eye tests done while taking this medicine. Stop taking it and inform your doctor immediately if you notice any changes in your vision.
- It can cause lowering of blood glucose level. Inform your doctor if you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor, and anxious feeling.
Brief Description
Indication
Acute and chronic rheumatoid arthritis, Systemic Lupus Erythematosus (SLE), Malaria
Administration
Should be taken with food.
Adult Dose
Oral
Malaria
Acute treatment
800 mg PO, then 400 mg PO 6-8 hours later, then 400 mg PO at 24 and 48 hours
Prophylaxis
400 mg PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from area
Rheumatoid Arthritis
400-600 mg PO daily for 4-12 weeks; maintenance: 200-400 mg PO daily
Systemic Lupus Erythematosus
400 mg PO once or twice daily; maintenance: 200-400 mg PO daily
Hepatic impairment: Estimation of plasma hydroxychloroquine levels to be undertaken in patients with severely compromised function and dosage adjusted accordingly.
Child Dose
Malaria
Acute treatment
13 mg/kg base PO, then 6.5 mg/kg base PO 6 hr later, then 6.5 mg/kg base PO at 24 and 48 hours; not to exceed 400 mg/day base
Prophylaxis
6.5 mg/kg base (not to exceed 400 mg [310 mg base]) PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from area
Renal Dose
Renal impairment: Estimation of plasma hydroxychloroquine levels to be undertaken in patients with severely compromised function and dosage adjusted accordingly.
Contraindication
The presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, patients with known hypersensitivity to 4-aminoquinoline compounds, long term therapy in children.
Mode of Action
Hydroxychloroquine is a 4-aminoquinoline antimalarial with actions similar to those of chloroquine but is mainly used in the treatment of SLE and rheumatoid arthritis. It interferes with digestive vacuole function within susceptible malarial parasites by increasing pH and interrupting with lysosomal degradation of Hb thus impeding normal cell function of sensitive parasites.
Precaution
Impaired liver or renal function, severe GI disorders, porphyria, psoriasis, neurological disorders especially a history of epilepsy, myasthenia gravis, G6PD deficiency, pregnancy, lactation. Monitor CBC in patients receiving prolonged therapy. Perform baseline and periodic 6-mth eye exams, test periodically for muscle weakness.
Lactation: Drug is concentrated in breast milk (American Academy of Pediatrics committee states that it is compatible with nursing)
Side Effect
Retinopathy, hair loss, photosensitivity, tinnitus, myopathy (long-term therapy). Psychosis, seizures, leucopenia and rarely aplastic anaemia, hepatitis, GI upsets, dizziness, hypokalaemia, headache, pruritus, urticaria, difficulty in visual accommodation. Loss of hair, bleaching of hair pigment, bluish-black pigmentation of the mucous membranes and skin, photosensitivity, tinnitus, reduced hearing, nerve deafness, neuromyopathy, and myopathy, including cardiomyopathy.
Interaction
Cimetidine may increase serum levels of hydroxychloroquine. Its absorption may be decreased by kaolin or Mg trisilicate. Avoid digoxin and alcohol. Increased risk of ventricular arrhythmias when used with halofantrine. Concurrent use with mefloquine may increase the risk of convulsions.
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