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Triokit
Opsonin Pharma Limited
Generic: Amoxicillin + Clarithromycin + Lansoprazole Kit
Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking Triokit may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR
Triokit may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Triokit is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Triokit may cause side effects which could affect your ability to drive.
Triokit can have side effects and the symptoms (such as allergic reactions, dizziness and convulsions) may make you unfit to drive.
CAUTION
Triokit should be used with caution in patients with kidney disease. Dose adjustment of Triokit may be needed. Please consult your doctor.
Use of this medicine is not recommended in patients with severe kidney disease.
SAFE IF PRESCRIBED
Triokit is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Triokit may not be needed in these patients. Please consult your doctor.
Medicine Overview of Triokit 30mg+500mg+1gm Tablet
Introduction
Triokit is a combination medicine used in the treatment of peptic ulcer disease by relieving the symptoms such as heartburn, indigestion, stomach pain, and irritation. It works by killing the ulcer-causing bacteria H. pylori. Triokit is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know...
... Show moreUses of Triokit
- Peptic ulcer disease
Side effects of Triokit
Common
- Nausea
- Diarrhea
- Stomach pain
- Flatulence
- Indigestion
- Tiredness
- Dizziness
- Headache
- Skin rash
- Metallic taste
- Dryness in mouth
How to use Triokit
Take this medicine in the dose and duration as advised by your doctor. Check the label before use. Triokit is to be taken empty stomach.
How Triokit works
Triokit is a combination of 2 antibiotics (Tinidazole and Amoxycillin) and a proton pump inhibitor (PPI-Lansoprazole) which treat peptic ulcers caused by bacteria. Tinidazole reduces the amount of acid in the stomach and allows healing of ulcers. Amoxycillin kills bacteria and other microorganisms that cause infections by damaging their DNA. Lansoprazole works by preventing the formation of the bacterial protective covering that is essential for the survival of bacteria. Together, they treat your infection effectively.
Quick Tips
- Triokit is a combination of three medicines which treats stomach/intestinal ulcers by killing the causative bacteria.
- Finish the prescribed course of medicine, even if you start to feel better. Stopping it early may make the ulcer come back and harder to treat.
- Stop taking Triokit and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Brief Description
Indication
Oral
Eradication of H. pylori to reduce risk of duodenal ulcer recurrence
Lansoprazole 30 mg, amoxicillin 1 g, clarithromycin 500 mg administered together PO twice daily (morning and evening) for 10 or 14 days
Hepatic impairment: No dosage adjustment needed with hepatic impairment
Administration
Amoxicillin: May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin. Clarithromycin: Serious adverse reactions have been reported in patients taking Clarithromycin concomitantly with CYP3A4 substrates. These include colchicine toxicity with colchicine; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; and hypotension and acute kidney injury with calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, amlodipine, diltiazem, nifedipine). Most reports of acute kidney injury with calcium channel blockers metabolized by CYP3A4 involved elderly...
... Show moreAdult Dose
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy, including amoxicillin. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens.
Lactation: Not recommended
Renal Dose
Lamsoprazole: Proton pump inhibitor; binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells resulting in blocking acid secretion.
Amoxicillin: Inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins that in turn inhibit the final transpeptidation step of peptoglycan synthesis in cell wall biosynthesis.
Clarithromycin: Inhibits protein synthesis by binding to 50S ribosomal subunit causing antibacterial activity.
Mode of Action
Combination therapy (lansoprazole, amoxicillin, clarithromycin) indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1-year history of a duodenal ulcer) to eradicate H. pylori
To reduce development of drug-resistant bacteria and maintain efficacy of antibacterial drugs, use only to treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria
Precaution
H. pylori infection, Peptic ulcer disease, Duodenal Ulcer
Side Effect
CrCl< 30 mL/min: Do not use
Pregnancy Category Note
>10% Clarithromycin GI effects, general (13%) 1-10% Clarithromycin Headache (6%),Rash (children 3%),Abdominal pain (adults 2%, children 3%),Abnormal taste (adults 3-7%),Diarrhea (3-6%),Dyspepsia (2%),Heartburn (adults 2%),GI intolerance (oral-dose related),Nausea (adults 3-6%),Vomiting (adults 1%; children 6%),Decreased WBC, elevated BUN (4%), elevated PT (1%) Lansoprazole Fatigue (< 3%),Headache (2.5-4.7%),Abdominal pain (1.8%),Diarrhea (8%),Nausea (3.7%) <1% Clarithromycin QT prolongation,Anxiety, dizziness, hallucinations, manic behavior, neuromuscular blockade, psychosis, seizures,Anorexia, glossitis, pancreatitis,AST increased, bilirubin increased, elevated LFTs, hepatic dysfunction, hepatitis, increased alkaline phosphate, jaundice,Hypoglycemia, leukopenia, neutropenia, thrombocytopenia,Increased serum creatinine,Dyspnea,Anaphylaxis, C Diff colitis, Stevens-Johnson syndrome Frequency Not Defined Amoxicillin Headache,Rash,Diarrhea, nausea, vomiting,Anemia,AST/ALT elevation,Acute exanthematous pustulosis,Exfoliative dermatitis Seizure,Insomnia,Hemorrhagic colitis,Toxic epidermal necrolysis,Urticaria,Stevens-Johnson...
... Show moreInteraction
Contraindicated in patients with known severe hypersensitivity to any component. Clarithromycin is contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of clarithromycin. Clarithromycin should not be given to patients with history of QT prolongation or ventricular cardiac arrhythmia, including torsades de pointes. A history of severe hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin or other beta-lactam antibiotics (e.g., penicillins and cephalosporins) is a contraindication. Clarithromycin is contraindicated in patients with a known hypersensitivity to clarithromycin, erythromycin, or any of the macrolide antibiotics. Clarithromycin is contraindicated in patients with a history of cholestatic...
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