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Nibalap 250

Tablet-(250mg)
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Aristopharma Limited

Generic: Lapatinib

12 Tablets (1 Box)
৳ 3780
৳ 4200
10% OFF
Alternative Brands For Nibalap 250

Medicine Overview of Nibalap 250mg Tablet

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Introduction

Nibalap 250 is used in the treatment of breast cancer. It shows its working by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced stage of breast cancer. Nibalap 250 should be taken on an empty stomach or should be taken one hour before or 2 hour after meal. You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your need and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine, inform your doctor if you notice severe headache, confusion, problems with your eyesight, nausea or vomiting. It might cause serious skin reaction, inform your doctor if you notice rash, red skin, blistering of the lips, eyes or mouth, skin peeling. You may be also checked for liver functioning before and after the treatment. Before taking this medicine, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Nibalap 250

  • Breast cancer

Side effects of Nibalap 250

Common
  • Abdominal pain
  • Back pain
  • Breathing problems
  • Constipation
  • Cough
  • Diarrhea
  • Fatigue
  • Headache
  • Hot flashes
  • Increased bilirubin in the blood
  • Insomnia (difficulty in sleeping)
  • Joint pain
  • Liver damage
  • Loss of appetite
  • Mucosal inflammation
  • Nausea
  • Pain in extremity
  • Rash
  • Stomatitis (Inflammation of the mouth)
  • Vomiting
  • Weakness
  • Weight gain

How to use Nibalap 250

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nibalap 250 is to be taken empty stomach.

How Nibalap 250 works

Nibalap 250 is an anti-cancer medication. This works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which is responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.

Quick Tips

  • It should be taken 1 hour before or after the meal, preferably at the same time every day.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
  • Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
  • It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
  • Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Brief Description

Indication

Breast cancer

Administration

Should be taken on an empty stomach. Take at least 1 hr before or 1 hr after a meal. Do not eat/drink grapefruit products.

Adult Dose

Oral Breast Cancer HER2-overexpressing metastatic breast cancer Indicated in combination with capecitabine for treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab 1250 mg PO qDay on Days 1-21 continuously in combination with capecitabine (2000 mg/m²/day PO divided q12hr) on Days 1-14 in a repeating 21-day cycle Hormone-positive & HER2-positive advanced breast cancer Indicated in combination therapy with letrozole for treatment of postmenopausal women with hormone receptor-positive and HER2-positive breast cancer for whom hormonal therapy is indicated 1500 mg PO qDay administered continuously in combination with letrozole 2.5 mg PO qDay Hepatic Impairment Severe (Child-Pugh Class C) HER2 positive metastatic breast cancer: Reduce dose from 1250 mg/day to 750 mg/day Hormone receptor positive, HER2 positive breast cancer: Reduce dose from 1500 mg/day to 1000 mg/day

Child Dose

Safety and efficacy not established

Contraindication

Hypersensitivity to lapatinib ditosylate

Mode of Action

Kinase inhibitor, blocks EGF-receptor HER2 kinase; tyrosing kinase inhibition possibly blocks angiogenesis and cellular proliferation.

Precaution

Evaluate left ventricular ejection fraction (LVEF) prior to treatment. Moderate or severe hepatic impairment. Patients who have or may develop QTc prolongation, including those w/ hypokalaemia or hypomagnesemia. Monitor liver function & pulmonary symptoms indicative of interstitial lung disease/pneumonitis. Pregnancy & lactation. Lactation: Do not nurse

Side Effect

>10% (lapatinib+capecitabine) Diarrhea (65%),Anemia (56%),Hand-foot synd (53%),Increased LFTs (37-49%),Nausea (44%),Rash (28%),Vomiting (26%),Pain (23%),Neutropenia (22%),Thrombocytopenia (18%),Mucositis (15%),Stomatitis (14%),Dyspnea (12%),Dyspepsia (11%),Insomnia (10%) 1-10% Insomnia

Interaction

Increased conc w/ CYP3A4 inhibitors (eg ketoconazole, itraconazole or grapefruit juice), midazolam, irinotecan & digoxin. Decreased conc w/ CYP3A4 inducers (eg rifampin, carbamazepine, phenytoin) & proton-pump inhibitors (eg esomeprazole). Altered pharmacokinetics w/ P-glycoprotein, breast cancer resistance protein (BCRP) inhibitors & inducers, topotecan & rosuvastation. Increased incidence & severity of adverse events w/ paclitaxel & docetaxel. CYP3A4 or CYP2C8 substrates.

Buy Nibalap 250 from Arogga

In Bangladesh, you can get the original Nibalap 250. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Nibalap 250 in Bangladesh?

The latest price of Nibalap 250 in Bangladesh is 3780৳. You can buy Nibalap 250 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Nibalap 250. Please consult your doctor.
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CONSULT YOUR DOCTOR
Nibalap 250 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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UNSAFE
Nibalap 250 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
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UNSAFE
Nibalap 250 may cause side effects which could affect your ability to drive.
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CAUTION
Nibalap 250 should be used with caution in patients with severe kidney disease. Dose adjustment of Nibalap 250 may be needed. Please consult your doctor. Limited information is available on the use of Nibalap 250 in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
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CAUTION
Nibalap 250 should be used with caution in patients with liver disease. Dose adjustment of Nibalap 250 may be needed. Please consult your doctor. Limited information is available on the use of this medicine in patients with the severe liver disease.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.