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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Lura 40.
SAFE IF PRESCRIBED
Lura 40 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Lura 40 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Lura 40 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Lura 40 should be used with caution in patients with kidney disease. Dose adjustment of Lura 40 may be needed. Please consult your doctor.
CAUTION
Lura 40 should be used with caution in patients with liver disease. Dose adjustment of Lura 40 may be needed. Please consult your doctor.
Medicine Overview of Lura 40mg Tablet
Introduction
Lura 40 is a prescription medicine used in the treatment of schizophrenia, a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave. It can also be used to treat depression, mania and bipolar disorders. Lura 40 should be taken with food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it...
... Show moreUses of Lura 40
- Schizophrenia
Side effects of Lura 40
Common
- Nausea
- Vomiting
- Weight gain
- Sleepiness
- Dryness in mouth
- Indigestion
- Parkinsonism
- Akathisia (inability to stay still)
- Anxiety
- Stomach discomfort
- Restlessness
- Upper abdominal pain
- Agitation
- Insomnia (difficulty in sleeping)
- Increased saliva production
How to use Lura 40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lura 40 is to be taken with food.
How Lura 40 works
Lura 40 work by modulating the action of certain chemical messengers in the brain that affects thoughts.
Quick Tips
- Lura 40 helps treat schizophrenia.
- It has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm as compared to other similar medicines.
- Use caution while driving or doing anything that requires concentration as Lura 40 can cause dizziness and sleepiness.
- Do not consume alcohol while on treatment with this medicine as it may worsen the side effects.
- Inform your doctor if you notice any abnormal or uncontrolled movements.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking this medicine without talking to your doctor first as it may cause worsening of symptoms.
Brief Description
Indication
Psychotic Disorder, Schizophrenia, bipolar depression.
Administration
Should be taken with food
Adult Dose
Schizophrenia
40 mg PO once daily initially; may increase to 80 mg/day if needed; not to exceed 160 mg/day
Bipolar Depression
Indicated for major depressive episodes associated with bipolar I disorder; may be used as either monotherapy or adjunctive therapy with lithium or valproate
20 mg PO once daily initially; may increase dose if needed, not to exceed 120 mg/day
Hepatic impairment
Mild (Child-Pugh class A): Dosage adjustment may not be necessary; use caution
Moderate (Child-Pugh class B): 20 mg/day initially; not to exceed 80 mg/day
Severe (Child-Pugh class C): 20 mg/day initially; not to exceed 40 mg/day
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl 50 mL/min or greater: Dosage adjustment not required
CrCl <50 mL/min: 20 mg/day initially; not to exceed 80 mg/day
Contraindication
Hypersensitivity. Concurrent administration of strong CYP3A4 inhibitors (eg, Ketoconazole). Concurrent administration of strong CYP3A4 inducers (eg, Rifampin).
Dementia-related psychosis.
Mode of Action
The mechanism of action of Lurasidone in the treatment of schizophrenia and bipolar depression is unknown. However, its efficacy in schizophrenia and bipolar depression could be mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.
Precaution
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants Cerebrovascular adverse reactions in elderly patients with dementia-related psychosis: Increased incidence of cerebrovascular adverse events (e.g., stroke, transient ischemic attack). Neuroleptic malignant syndrome: Manage with immediate discontinuation and close monitoring. Tardive dyskinesia: Discontinue if clinically appropriate. Metabolic changes: Atypical antipsychotic drugs have been associated with metabolic changes that may increase cardiovascular/cerebrovascular risk. These metabolic changes include hyperglycemia, dyslipidemia, and weight gain. Hyperglycemia and diabetes mellitus: Monitor patients for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Monitor glucose regularly in patients with diabetes or...
... Show moreSide Effect
>10%
Somnolence, dose related (22%),Akathisia, dose related (15%),Fasting glucose increased (10-14%),Nausea (12%),Parkinsonism (11%)
1-10%
Vomiting (8%),Dyspepsia (8%),Anxiety (8%),Agitation (6%),Anxiety (6%),Dystonia (5%),Dizziness (5%),Fatigue (4%),Back pain (4%),Restlessness (3%),Salivary hypersecretion (2%)
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