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Cisplatin PhaRes

Injection-(1mg/ml)
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ZAS Corporation

Generic: Cisplatin

1 x 10mg Vial
৳ 705.23
৳ 735
4% OFF
Alternative Brands For Cisplatin PhaRes

Medicine Overview of Cisplatin PhaRes 1mg/ml Injection

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Introduction

Cisplatin PhaRes is used in the treatment of ovarian, cervical and testicular cancer. It shows its working by stopping or slowing down the growth of cancer cells. Cisplatin PhaRes is given as an injection into veins by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Injection site reaction (pain, swelling, redness), nausea and vomiting are some common side effects of this medicine. Hearing problem or ear damage is serious side effect of this medicine, hence your doctor might check you for hearing test before and after the treatment. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and kidney. Before taking this medicine, let your doctor know about kidney disease as medicine affect the functioning of the kidney. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It makes men infertile, hence men should take doctor advice about the freezing of sperm before the treatment.

Uses of Cisplatin PhaRes

  • Ovarian cancer
  • Cervical cancer
  • Testicular cancer

Side effects of Cisplatin PhaRes

Common
  • Injection site reactions (pain, swelling, redness)
  • Increased risk of infection
  • Ear disorder
  • Vomiting
  • Nausea
  • Decreased blood cells (red cells, white cells, and platelets)
  • Renal impairment
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Kidney damage
  • Hearing loss
  • Ringing in ear

How to use Cisplatin PhaRes

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

How Cisplatin PhaRes works

Cisplatin PhaRes is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.

What if you forget to take Cisplatin PhaRes?

If you miss a dose of Cisplatin PhaRes, please consult your doctor.

Quick Tips

  • Cisplatin PhaRes is given as an injection under the supervision of a doctor.

Brief Description

Indication

Lymphomas, Sarcomas, Carcinomas, Small cell lung cancer, Ovarian cancer, Germ cell tumors, Metastatic Testicular Tumors, Metastatic Ovarian Tumors, Advanced Bladder Cancer

Administration

IV Preparation Further dilution stability is dependent on chloride ion concentration & should be mixed in solutions of NS (at least 0.3% NaCl) Further dilution in NS, D5/½NS or D5/NS to a concentration of 0.05-2 mg/mL are stable for 72 hr at 4-25°C in combination with mannitol May administer 12.5-50 g mannitol/L Standard dilution: dose/250-1000 mL NS, D5W/NS or D5/½NS IV Administration Perform pretreatment hydration Do not use aluminum-containing needles or IV administration sets that may come in contact with carboplatin (aluminum can react causing precipitate formation & loss of potency) Administration rate has varied from a 15-120 min infusion, 1 mg/min infusion, 6-8 hr infusion, 24 hr infusion, or per protocol Maximum rate of infusion: 1 mg/min in patients with CHF When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before platinum derivatives to limit myelosuppression & to enhance efficacy

Adult Dose

Metastatic Testicular Tumors Usual dose in combination with other approved chemotherapeutic agents is 20 mg/m²/day IV for 5 days/cycle Pretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr <1.5 mg/dL [<133 micromoles/L] or BUN <25 mg/dL [<8.93 mmol/L] or WBC >4000/mm³ AND platelets >100 k/mm³ Advanced Bladder Cancer 50-70 mg/m² IV cycle q3-4Weeks, depending on prior radiation therapy or chemotherapy; for heavily pretreated patients, give 50 mg/m²/cycle initially; repeat q4Weeks Pretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr <1.5 mg/dL [<133 micromoles/L] or BUN <25 mg/dL [<8.93 mmol/L] or WBC >4000/mm³ AND platelets >100 k/mm³ Metastatic Ovarian Carcinoma 75-100 mg/m² IV per cycle q4Weeks with cyclophosphamide (600 mg/m² IV q4Weeks); administer sequentially Off-label: 90-270 mg/m² intraperitoneal; retain for 4 hr before draining; repeat q3Weeks (may coadminister systemic Na thiosulfate) Pretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr <1.5 mg/dL [<133 micromoles/L] or BUN <25 mg/dL [<8.93 mmol/L] or WBC >4000/mm³ AND platelets >100 k/mm³

Renal Dose

Renal Impairment CrCl 10-50 mL/min: Decrease dose 50% CrCl <10 mL/min: Contraindicated

Contraindication

Patients with severe renal or auditory disorder, known hypersensitivity, severe bone marrow suppression, peripheral neuropathy, pregnancy, lactation.

Mode of Action

Cisplatin modifies cell cycle by interfering with DNA structure and function. Effects are most prominent during the S phase but cells are killed at all stages. Cisplatin synergises with other anticancer drugs e.g. fluorouracil. It has a narrow therapeutic margin and is highly toxic.

Precaution

Patients with renal or hepatic disorder, myelosuppression. Monitor renal, neurological and auditory function. Perform blood counts regularly. Maintain adequate hydration before and 24 hr after admin to minimise nephrotoxicity. Lactation: excreted in breast milk; do not nurse

Side Effect

>10% Nausea (76-100%),Vomiting (76-100%),Nephrotoxicity (28-36%),Ototoxicity, especially in children (31%),Myelosuppression (25-30%),Anaphylaxis (1-20%),Alopecia Frequency Not Defined Cerebral herniation,Encephalopathy,Leukoencephalopathy and reversible posterior leukoencephalopathy syndrome,Seizure,Peripheral neuropathy (dose and duration dependent),Diarrhea,Electrolyte changes,Hyperuricemia,Hepatotoxicity,Local tissue irritation Potentially Fatal: Rarely, renal damage due to inadequate hydration during therapy. Very rarely life-threatening myelosuppression. Anaphylactoid reactions (rare) and cardiac abnormalities.

Pregnancy Category Note

Pregnancy Based on human data from published literature, cisplatin can cause fetal harm when administered to pregnant women; data demonstrates transplacental transfer of cisplatin Exposure associated with oligohydramnios, intrauterine growth restriction, and preterm birth; cases of neonatal acute respiratory distress syndrome, cytopenias, and hearing loss reported Verify the pregnancy status of females of reproductive potential before initiating prior to initiation of cisplatin for injection Contraception Females: Advise females of reproductive potential to use effective contraception during treatment and for 14 months following the last dose Males: Advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 11 months after the last dose Infertility Females: Use associated with cumulative dose-dependent ovarian failure, premature menopause, and reduced fertility Males: Use associated with a cumulative dose-dependent impairment of spermatogenesis (oligospermia, azoospermia; possibly irreversible) and reduced fertility Lactation Limited data from published literature report the presence of drug in human milk; because of potential for serious adverse reactions in a breastfed child and because of potential for tumorigenicity, advise lactating women not to breastfeed during treatment

Interaction

Synergistic with 5-fluorouracil and etoposide. Efficacy increased and toxicity reduced when combined with radioprotecting agent WR 2721. At doses ?100 mg, cisplatin is an ideal drug to combine with other cytotoxic drugs; unlike other antineoplastic drugs, it causes little myelosuppression. Potentially Fatal: Potentiates nephrotoxicity with aminoglycosides. Increased toxicity when combined with other cytotoxic drugs.

Buy Cisplatin PhaRes from Arogga

In Bangladesh, you can get the original Cisplatin PhaRes. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Cisplatin PhaRes in Bangladesh?

The latest price of Cisplatin PhaRes in Bangladesh is 705.23৳. You can buy Cisplatin PhaRes at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Cisplatin PhaRes. Please consult your doctor.
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CONSULT YOUR DOCTOR
Cisplatin PhaRes is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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UNSAFE
Cisplatin PhaRes is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
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UNSAFE
Cisplatin PhaRes may cause side effects which could affect your ability to drive. Cisplatin PhaRes may cause side effects such as feeling sleepy and/or vomiting which could affect your ability to drive.
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CAUTION
Cisplatin PhaRes should be used with caution in patients with kidney disease. Dose adjustment of Cisplatin PhaRes may be needed. Please consult your doctor. Use of Cisplatin PhaRes is not recommended in patients with severe kidney disease.
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SAFE IF PRESCRIBED
Cisplatin PhaRes is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Cisplatin PhaRes may not be needed in these patients. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.