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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Clocef.
SAFE IF PRESCRIBED
Clocef is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Clocef is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Clocef, since it may have possible effects such as rash and diarrhea.
CONSULT YOUR DOCTOR
It is not known whether Clocef alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Clocef should be used with caution in patients with kidney disease. Dose adjustment of Clocef may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Clocef in patients with liver disease. Please consult your doctor.
Medicine Overview of Clocef 500mg Capsule
Introduction
Clocef is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (e.g. pneumonia), ear, throat, nasal sinus, urinary tract, skin, soft tissues, bones, and joints. It is also used to prevent infections during surgery. Clocef may be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always...
... Show moreUses of Clocef
- Bacterial infections
Side effects of Clocef
Common
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Injection site reaction
- Increased liver enzymes
- Diarrhea
How to use Clocef
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clocef may be taken with or without food, but it is better to take it at a fixed time.
How Clocef works
Clocef is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Clocef?
If you miss a dose of Clocef, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Uniclor 375mg Tablet MR to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
- Discontinue Uniclor 375mg Tablet MR and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Take it with food to avoid an upset stomach.
- Avoid consuming alcohol while taking Uniclor 375mg Tablet MR as it may cause increased side effects.
Brief Description
Indication
Pneumonia, Meningitis, Peritonitis, Otitis media, Septicaemia, Biliary-tract infections, Urinary-tract infections, Skin and skin structure infections, Upper and lower respiratory tract infections, Pharyngitis, Tonsillitis
Administration
May be taken with or without food.
Adult Dose
Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Adult: As monohydrate: 250-500 mg every 8 hr. Max: 4 g daily.
Child Dose
Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Child: PO 20–40 mg/kg/day, max 1 g/day q12h
1-5 yr: 125 mg tid,
>5 yr: 250 mg tid.
Suspension & Paediatric Drops:
1 month - 1 year 2.5 ml t.i.d. 0.625 ml t.i.d
1 year - 5 year 5 ml t.i.d. 1.25 ml t.i.d
over 5 years 10 ml t.i.d 2.5 ml t.i.d
Renal Dose
Renal Impairment
CrCl: 10-50 mL/min: Half to full dose
CrCl: <10 mL/min: Half dose
Contraindication
Known hypersensitivity to cephalosporins.
Mode of Action
Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.
Precaution
Severe renal impairment; history of allergy to penicillin; pregnancy, lactation.
Lactation: enters breast milk; use with caution
Side Effect
1-10%
Diarrhea (3%),Increased transaminases (3%),Eosinophilia (2%),Moniliasis (2%),Vaginitis (2%),Rash (maculopapular, erythematous, or morbiliform) (1-2%)
<1%
Stevens-Johnson syndrome,Pseudomembranous colitis,Nausea,Vomiting,Anemia,Neutropenia,Jaundice
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Pregnancy Category Note
Pregnancy
No adequate and well-controlled studies in pregnant women
Because animal reproduction studies are not always predictive of human response, cefaclor should be used during pregnancy only if necessary
Lactation
Effect on nursing infants is unknown; exercise caution when cefaclor is administered to a nursing woman
Extended-release tablets
No studies in lactating women performed; small amounts of cefaclor (?0.21 mcg/mL) detected in human milk following administration (single 500-mg dose of cefaclor extended-release tablets)
Interaction
May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.
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