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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Riluzol. Please consult your doctor.
CONSULT YOUR DOCTOR
Riluzol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Riluzol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Riluzol may cause side effects which could affect your ability to drive.
You may feel dizzy or light headed after taking this medicine. This may affect your driving ability.
CONSULT YOUR DOCTOR
There is limited information available on the use of Riluzol in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Riluzol in patients with liver disease. Please consult your doctor.
Medicine Overview of Riluzol 5mg/1ml Suspension
Introduction
Riluzol is a prescription medicine used in the treatment of amyotrophic lateral sclerosis (ALS), a degenerative disease that weakens muscles and hence affects the overall physical function. Riluzol modifies the action of glutamate, a chemical messenger involved in the transmission of nerve signals in the brain. This medicine is taken on an empty stomach, either 1 hour before or 2 hours after meals. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is...
... Show moreUses of Riluzol
- Amyotrophic lateral sclerosis (ALS)
Side effects of Riluzol
Common
- Weakness
- Headache
- Dizziness
- Nausea
- Abdominal pain
- Diarrhea
- Decreased pulmonary function
- Paresthesia (tingling or pricking sensation)
- Sleepiness
- Increased heart rate
- Vomiting
- Pain
- Abnormal liver function tests
How to use Riluzol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Riluzol is to be taken empty stomach.
Avoid Riluzol with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat.
How Riluzol works
Riluzol is a glutamate antagonist and used an an anticonvulsant (anti fits). It is believed to work by inhibiting the action of glutamate (chemical messenger) and also inactivates the voltage-dependent sodium channels. In this way it regulates the transmission of nerve signals in the brain.
Quick Tips
- Take it twice a day, 1 hour before or 2 hours after the meal, preferably at the same time.
- It may cause sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- Avoid smoking as it may make Riluzol less effective.
- Your doctor may monitor your liver function, lung function and blood count while you are taking this medicine. Inform your doctor if you develop yellowing of the skin, abdominal pain, fever, sore throat, new cough or shortness of breath while taking this medicine.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Amyotrophic lateral sclerosis
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.
Adult Dose
Oral
Amyotrophic lateral sclerosis
Adult: 50 mg bid. Discontinue if ALT levels increase to 5 times the upper limit of normal (ULN).
Hepatic impairment
Mild or moderate (Child-Pugh A or B): Patients had increases in AUC; thus, may be at increased risk of adverse reactions
Severe (Child-Pugh C): Unknown
Not recommended for patients with baseline serum aminotransferases (AST/ALTs) >5x ULN or evidence of liver dysfunction (eg, elevated bilirubin)
Contraindication
Hepatic impairment (baseline transaminases >3 times the upper limit of normal).
Mode of Action
Riluzole is a glutamate inhibitor used to slow disease progression and prolong survival rate in patients with amyotrophic lateral sclerosis. The exact mechanism of its action is not fully elucidated but is shown to inhibit the release of glutamate, inactivate voltage-dependent Na channels, and interfere with intracellular events following binding of transmitter at excitatory amino acid receptors.
Precaution
Patient with history of liver diseases. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness or vertigo, if affected, do not drive or operate machinery. Monitoring Parameters Monitor serum aminotransferase concentrations (e.g. ALT) before and during therapy; signs and symptoms of hepatic injury.
Side Effect
>10%
Oral hypoesthesia (29%)
Asthenia (19%)
Nausea (16%)
1-10%
Decreased lung function (10%)
Hypertension (5%)
Abdominal pain (5%)
Vomiting (4%)
Arthralgia (4%)
Dizziness (4%)
Dry mouth (4%)
Insomnia (4%)
Pruritus (4%)
Tachycardia (3%)
Flatulence (3%)
Increased cough (3%)
Peripheral edema (3%)
Urinary tract infection (3%)
Circumoral paresthesia (2%)
Somnolence (2%)
Vertigo (2%)
Eczema (2%)
Pregnancy Category Note
Pregnancy There are no studies in pregnant women, and case reports have been inadequate to inform of drug-associated risk Unknown if risk of major birth defects and miscarriage in patients with amyotrophic lateral sclerosis Animal data In studies in which riluzole was orally administered to pregnant animals, developmental toxicity (decreased embryofetal/offspring viability, growth, and functional development) was observed at clinically relevant doses Based on these results, advise women of possible risks to fetus associated with use of riluzole during pregnancy In rats, oral administration of riluzole resulted in decreased fertility indices and increases in embryo lethality Lactation Unknown if distributed...
... Show moreInteraction
Decreased rate of elimination with CYP1A2 inhibitors (e.g. caffeine, ciprofloxacin, oral contraceptives). Increased rate of elimination with CYP1A2 inducers (e.g. rifampicin, omeprazole). Increased risk of hepatotoxicity with hepatotoxic drugs (e.g. allopurinol, methyldopa, sulfasalazine).
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