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Labegest
Incepta Pharmaceuticals Ltd.
Generic: Labetalol Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Labegest.
CONSULT YOUR DOCTOR
Labegest may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Labegest is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Labegest may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Labegest is safe to use in patients with kidney disease. No dose adjustment of Labegest is recommended.
However, talk to your doctor if you have any underlying kidney disease. Regular monitoring of blood pressure is recommended for better dose adjustment.
CAUTION
Labegest should be used with caution in patients with liver disease. Dose adjustment of Labegest may be needed. Please consult your doctor.
Medicine Overview of Labegest 5mg/ml Injection
Introduction
Labegest is a medicine used for treating high blood pressure (hypertension) and heart-related chest pain (angina). It is also effective for treating high blood pressure in pregnancy. It lowers the blood pressure and thus helps in preventing future stroke and heart attack. Labegest may be used alone or in combination with other medicines. It should be taken with food. You can take it at any time of day but try to take it at the same time each day. Since it can cause serious withdrawal effects, it should not be stopped abruptly. Most people with high blood pressure do not...
... Show moreUses of Labegest
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- Prevention of heart attack and stroke
Side effects of Labegest
Common
- Dizziness
- Allergic reaction
- Ejaculation disorder
- Increased liver enzymes
- Difficulty in urination
How to use Labegest
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Labegest is to be taken with food.
How Labegest works
Labegest is an alpha and beta blocker. It works by slowing down the heart rate and relaxing blood vessels which makes the heart more efficient at pumping blood around the body.
Quick Tips
- It should be taken with food.
- Check your blood pressure 1 week after starting Labegest, and inform your doctor if it has not improved.
- Labegest may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down.
- It is best to avoid drinking alcohol while taking Labegest as it may make the side effects worse.
- Do not stop taking Labegest suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
Brief Description
Indication
Hypertension, Hypotensive anaesthesia
Administration
Should be taken with food. Take immediately after meals.
IV Preparation
Standard diluent: 500 mg/250 mL D5W
Minimum volume: 250 mL D5W
IV Administration
Requires infusion pump
Slow direct IV push administered over 2 minutes
Loading infusions (2 mg/min) require close monitoring of HR and BP and are terminated after response occurs or a cumulative dose of 300 mg is reached
Continuous infusions of 2-6 mg/hr have been used in some settings and should not be confused with loading infusions
Adult Dose
Oral Hypertension Adult: Initially, 100 mg bid, may increase gradually according to patients response to 200-400 mg bid. Max: 2.4 g/day in 2-4 divided doses. Elderly: Initially, 50-100 mg bid. Maintenance: 100-200 mg bid. Intravenous Emergency treatment of hypertension Adult: 20 mg injected slowly for at least 2 min, followed by 40-80 mg dose every 10 min, if necessary up to 300 mg. Patient should remain supine during and 3 hr after the procedure. Hypertension in pregnancy Adult: Start infusion at a rate of 20 mg/hr, doubled every 30 min until a satisfactory response is achieved or a dose of...
... Show moreChild Dose
Hypertensive Emergency
0.4-1 mg/kg/hr by continuous IV infusion; not to exceed 3 mg/kg/hr
Contraindication
2nd and 3rd degree heart block, cardiogenic shock, obstructive airway disease e.g. bronchial asthma, uncompensated heart failure, severe bradycardia, sick sinus syndrome, Prinzmetal's angina, severe peripheral arterial disease.
Mode of Action
Labetalol competitively inhibits the adrenergic stimulation of beta-receptors w/in the myocardium, bronchial and vascular smooth muscle, and alpha1-receptors w/in vascular smooth muscle. It also has some intrinsic beta2-agonist and membrane-stabilising activity.
Precaution
Phaeochromocytoma, compensated heart failure, nonallergic bronchospasm. Avoid abrupt withdrawal. DM. Hepatic impairment. Perform LFTs. Elderly. Pregnancy and lactation.
Lactation: Small amounts excreted; use with caution
Side Effect
>10%
Dizziness (1-20%),Lightheadedness (1-20%),Nausea (<19%),Tingling sensation of scalp (4-12%),Fatigue (1-11%)
1-10%
Elevated serum blood urea nitrogen (BUN) (<8%),Elevated serum creatinine (8%),Congestion of nasal sinus (1-6%),Orthostatic hypotension (1-5%),Absence of ejaculation (<5%),Paresthesia (<5%),Elevated liver enzymes (4%),Diaphoresis (<4%),Edema (<2%),Bronchospasm (1-2%),Dyspnea (1-2%),Pruritus (1%),Rash (1%),Altered taste sense (1%),Ventricular arrhythmia (1%; IV)
Frequency Not Defined
Angioedema,Bradycardia,Alopecia,Cholestatic jaundice,Depression,Diabetes insipidus,Hepatitis,Raynaud syndrome,Toxic myopathy,Urinary retention,Urticaria,Raynaud phenomenon
Potentially Fatal: Hepatic injury.
Interaction
Synergistic hypotensive effect w/ halothane. Increased absolute bioavailability w/ cimetidine. Decreased absolute bioavailability w/ glutethimide. Additive hypotensive effect w/ nitroglycerin. Increased incidence of tremor w/ TCAs. Increased risk of bradycardia and heart block w/ Ca channel blocker (e.g. verapamil, diltiazem).
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