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Criston 2

Injection-(2mg/vial)
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Beacon Pharmaceuticals PLC

Generic: Vincristine Sulphate

1 Injection
৳ 528.45
৳ 580
9% OFF
Alternative Brands For Criston 2

Medicine Overview of Criston 2mg/vial Injection

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Introduction

Criston 2 is an anti-cancer medication used in the treatment of breast cancer, non-small cell lung cancer, pancreatic cancer, kidney cancer, blood cancer, multiple myeloma, lymphomas and bone cancer. Criston 2 is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include hair loss, peripheral neuropathy (tingling and numbness of feet and hand), and constipation. This medicine may reduce the number of blood cells (white blood cells) in your blood, thereby, increasing the susceptibility to infections and fever. In some cases, it may also cause kidney disease related to uric acid level. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. you are suggested to avoid direct contact of medicine with eyes, as it may cause eye irritation.

Uses of Criston 2

  • Breast cancer
  • Non-small cell lung cancer
  • Pancreatic cancer
  • Kidney cancer
  • Blood cancer
  • Multiple myeloma
  • Lymphomas
  • Bone cancer

Side effects of Criston 2

Common
  • Hair loss
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Constipation

How to use Criston 2

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Criston 2 works

Criston 2 blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

Quick Tips

  • Avoid being near people suffering from infections (such as, cold, flu, contagious illnesses), as you may be more susceptible to infections, while on vincristine therapy, because of possibility of leukopenia.
  • Avoid even accidental contamination of eyes with vincristine as it may cause severe irritation.
  • Vincristine may cause acute kidney disease (nephropathy) related to uric acid level.
  • Care should be taken in elderly patients because they are more susceptible to neurotoxic effects of vincristine.
  • In males, vincristine may cause aspermia (lack of semen causing infertility); in females vincristine may cause amenorrhea (absence of menstruation), which may recover after some duration.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Brief Description

Indication

Acute lymphoblastic leukaemia, Acute myeloid leukaemia, AIDS-related Kaposi's sarcoma, Brain tumours, Hodgkin's disease, Neuroblastoma, Non-Hodgkin's lymphoma, Small cell lung cancer, Wilm's tumour

Adult Dose

Intravenous Acute lymphoblastic leukaemia Adult: Usual recommended dosage: 1.4-1.5 mg/m2 once wkly. Max: 2 mg wkly. Subsequent doses may be modified based on clinical and haematological responses and tolerance of the patient. May be used in combination with other drugs. Prescribers should consult published protocols for the dosage, method and sequence of admin. Hepatic impairment: Dose adjustment may be needed. Serum bilirubin >3 mg/100ml: Reduce dose by 50%.

Child Dose

Intravenous Acute lymphoblastic leukaemia Child: Usual recommended dosage: 1.5-2 mg/m2 once wkly; for patients ?10 kg: Initiate at 0.05 mg/kg once wkly. Subsequent doses may be modified based on clinical and haematological responses and tolerance of the patient. May be used in combination with other drugs. Prescribers should consult published protocols for the dosage, method and sequence of admin.

Renal Dose

Renal Impairment Dose adjustment not necessary

Contraindication

Patients with demyelinating form of Charcot-Marie-Tooth syndrome. Pregnancy and lactation. Intrathecal admin (may be fatal). Patients receiving radiation therapy through ports which include liver.

Mode of Action

Vincristine arrests cell division at the metaphase stage by inhibiting microtubule formation in the mitotic spindle.

Precaution

Elderly. Preexisting pulmonary dysfunction or neuromuscular disease; leucopenia or a complicating infection; impaired liver function; obstructive jaundice. Routine prophylactic laxative needed to ensure regular bowel movement. Discontinue immediately if extravasation occurs, and inj any remaining drug into another vein, followed by local Inj of hyaluronidase and topical heat application to the affected area to aid in drug removal and reduce discomfort. Discontinue in patients who develop progressive dyspnea. CBC to be checked before each dose admin. Frequent monitoring of uric acid during first 3-4 wk of treatment and watch out for uric acid nephropathy. Lactation: not known if excreted in breast milk, do not nurse

Side Effect

>10% Alopecia (20-70%) Frequency Not Defined Dose limiting neurotoxicity (e.g. motor function impairment, gait abnormalities), hyperuricaemia, bronchospasm, azospermia, amenorrhoea, alopoecia, leucopenia, urinary dysfunction, abdominal cramps, vomiting, diarrhoea, severe constipation, paralytic ileus, convulsions, hypertension, orthostatic hypotension, ptosis, hoarseness, optic neuropathies, hallucinations, blindness, neurological deafness, difficulty in walking, syndrome of inappropriate ADH secretion. Potentially Fatal: Myelosuppression.

Interaction

Decreased digoxin (tablets) and verapamil absorption with antineoplastic regimens. Increased etoposide serum levels with vincristine. Increased toxicity when ganciclovir given with, immediately before or after vincristine. Reduced vincristine metabolism with miconazole. Increased neurotoxicity with isoniazid, itraconazole, voriconazole, posaconazole and nifedipine. Decreased immune response when used concurrently with vaccines. Increased myelotoxicity with zidovudine. Increased risk of thromboembolic complications with tamoxifen. Increased risk of ototoxicity with ototoxic drugs (e.g. platinum-containing antineoplastic agents). Possible risk of earlier onset and/or increased severity of adverse effects with macrolides. Possible increase in vincristine levels with aprepitant. Possible decrease in antiepileptic levels with vincristine, monitor serum antiepileptic levels and effectiveness of chemotherapy. Potentially Fatal: Increased risk of bronchospasm with mitomycin C. Reduced vincristine clearance and increased toxicity with asparaginase, minimise toxicity by giving vincristine 12-24 hr before L-asparaginase admin.

Buy Criston 2 from Arogga

In Bangladesh, you can get the original Criston 2. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Criston 2 in Bangladesh?

The latest price of Criston 2 in Bangladesh is 528.45৳. You can buy Criston 2 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Criston 2. Please consult your doctor.
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CONSULT YOUR DOCTOR
Criston 2 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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UNSAFE
Criston 2 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
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UNSAFE
Criston 2 may cause side effects which could affect your ability to drive.
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CAUTION
Criston 2 should be used with caution in patients with kidney disease. Dose adjustment of Criston 2 may be needed. Please consult your doctor.
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CAUTION
Criston 2 should be used with caution in patients with liver disease. Dose adjustment of Criston 2 may be needed. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.