Out of stock
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
0 People recently viewed this
Dacarzin
Beacon Pharmaceuticals PLC
Generic: Dacarbazine
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Dacarzin. Please consult your doctor.
CONSULT YOUR DOCTOR
Dacarzin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Dacarzin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Dacarzin may cause side effects which could affect your ability to drive.
Dacarzin may influence the ability to drive because of its central nervous system side effects.
CAUTION
Dacarzin should be used with caution in patients with kidney disease. Dose adjustment of Dacarzin may be needed. Please consult your doctor.
CAUTION
Dacarzin should be used with caution in patients with liver disease. Dose adjustment of Dacarzin may be needed. Please consult your doctor.
Medicine Overview of Dacarzin 200mg/vial Injection
Introduction
Dacarzin is used in the treatment of cancers of lymphatic system and malignant melanoma (a type of skin cancer). It may be also used to treat other conditions, as determined by the doctor. Dacarzin is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking...
... Show moreUses of Dacarzin
- Malignant melanoma
- Hodgkin’s disease
Side effects of Dacarzin
Common
- Nausea
- Vomiting
- Injection site pain
- Decreased white blood cell count
- Loss of appetite
How to use Dacarzin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Dacarzin works
Dacarzin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Dacarzin?
If you miss a dose of Dacarzin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Dacarzin is given as an injection into veins under the supervision of a doctor.
Brief Description
Indication
Metastatic melanoma, Hodgkin's disease, Soft tissue sarcoma
Administration
IV Preparation
Reconstitute with a 9.9 mL (100 mg vial) or 19.7 mL (200 mg vial) of SWI to obtain a 10 mg/mL soln
For infusion, dilute with D5W or NS up to 250 mL
IV Administration
IVP over 1 min (may be irritant & painful) OR infusion over 15-60 min
Adult Dose
Intravenous
Metastatic melanoma
Adult: 2-4.5 mg/kg daily for 10 days, repeat at 4-wk intervals or 200-250 mg/m2 BSA daily for 5 days, repeat at 3-wk intervals or 850 mg/m2 BSA by infusion, repeat at 3-wk intervals.
Hodgkin's disease
Adult: 150 mg/m2 BSA daily for 5 days, repeat every 4 wk or 375 mg/m2 BSA every 15 days in combination with other agents.
Soft tissue sarcoma
Adult: 250 mg/m2 BSA daily for 5 days repeated every 3 wk. Usually given with doxorubicin.
Child Dose
Hodgkin's Disease
With other antineoplastics, eg ABVD
Dosage dependent on protocol150 mg/m² IV qDay for 5 days, repeat q4Weeks OR
375 mg/m² IV on Day 1; repeat every 15 Days
Contraindication
Bone marrow suppression; hypersensitivity.
Mode of Action
The exact mechanism of action is still unclear but it appears to form methylcarbonium ions that attack nucleophilic groups by attaching to the 7-position of guanine on DNA. It also cross-links DNA strands leading to inhibition of DNA, RNA and protein synthesis.
Precaution
Hepatic or renal impairment. Pregnancy, lactation.
Lactation: not known if excreted in breast milk, do not nurse
Side Effect
>10%
Nausea (>90%),Vomiting(>90%),Injection site pain,Leukopenia,Thrombocytopenia
1-10%
Alopecia,Rash,Photosensitivity,Anorexia,Metallic taste,Flu-like syndrome
Frequency Not Defined
Anaphylaxis,Photosensitivity (rare),Cerebral hemorrhage,Seizure,Myelosuppression,Hepatic necrosis,Hepatic vein thrombosis,Hepatotoxicity
Potentially Fatal: Myelosuppression; hepatotoxicity, anaphylaxis.
Pregnancy Category Note
Pregnancy Category: C
Lactation: not known if excreted in breast milk, do not nurse
Interaction
Impairs immune response to vaccines; possible infection after admin of live vaccines. Effect increased by CYP1A2 inhibitors e.g. amiodarone, ciprofloxacin, fluvoxamine, ketoconazole, lomefloxacin, ofloxacin and rofecoxib. Effect decreased by CYP1A2 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital and rifampicin.
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register