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Silimar 500
Neo Pharma Bangladesh
Generic: Silymarin [Milk thistle]
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Silimar 500.
CONSULT YOUR DOCTOR
Silimar 500 is not recommended for use during pregnancy. Controlled, long-term safety studies are lacking. Please consult your doctor.
CONSULT YOUR DOCTOR
No experience is available about the use of Silimar 500 .Long-term safety studies are lacking. Please consult your doctor.
SAFE IF PRESCRIBED
Limited research on the effects of Silimar 500 on driving ability.
CAUTION
It should be used with caution in patients with kidney disease. Dose adjustment of Silimar 500 may be needed. Please consult your doctor.
CAUTION
It should be used with caution in patients with liver disease. Dose adjustment of Silimar 500 may be needed. Please consult your doctor.
Medicine Overview of Silimar 500mg Capsule
Introduction
Silimar 500 is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Silimar 500 exhibits hepatoprotective and regenerative properties and is one of the most widely used natural compounds for the treatment of hepatic diseases worldwide, due to its antioxidant, anti-inflammatory, and antifibrotic activities. Silimar 500 also increases hepatic levels of glutathione by raising cysteine availability, while inhibiting its catabolism to taurine that may enhance the antioxidant defense in liver. Silimar 500 was found to oppose oxidative stress, and to slow the progression of hepatic fibrosis in alcohol-fed baboons.
Uses of Silimar 500
Silimar 500 is used for the treatment of Jaundice,chronic inflammatory liver conditions, hepatic cirrhosis ,alcoholic liver damage.
Side effects of Silimar 500
Sometimes it cause
- Mild digestive upset
- Allergic reactions
How to use Silimar 500
Take Silimar 500 in the dose and duration as advised by your doctor. Take Silimar 500 orally with plenty of water. Do not chew, crush or break it.
How Silimar 500 work
Different mechanisms of action of Silimar 500 are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as Silimar 500 has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of Silimar 500 is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp),...
... Show moreWhat if you forget to take Silimar 500
If you forget to take yourSilimar 500 , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.
Brief Description
Indication
It is used for the treatment and prevention of-
Liver disease, (non-alcoholic & alcoholic) ,
Liver cirrhosis, (non-alcoholic & alcoholic)
Infectious hepatitis,
Drug-induced hepatitis,
Liver disease secondary to diabetes mellitus,
Toxicity of narcotics,
Fatty liver,
Jaundice.
Administration
Administered only orally as advised by the physician.
Adult Dose
1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician.
Child Dose
It should not be given to children without advice of physician. Uses for below 12 years recommended after discussion
with registered physician.
Renal Dose
It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor.
Contraindication
Contraindicated in patient with a known hypersensitivity to silymarin.
Mode of Action
Different mechanisms of action of silymarin are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as silymarin has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of silymarin is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake...
... Show morePrecaution
Over doses may mildly elevate blood pressure. Safety in young children or individuals with severe hepatic or renal disease is not known.
Side Effect
Occasionally a mild laxative effect may observe. Well tolerated in the recommended dose.
Pregnancy & Lactation Category Note
Therefore, if needed Silymarin should be taken with caution according to the physician’s advice. No established evidence is available about the use of Silymarin during pregnancy and lactation.
Interaction
Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation.
Storage Condition
Store in a cool & dry place, away from light & moisture. Keep out of reach of children.
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