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Prugen 2
General Pharmaceuticals Ltd.
Generic: Prucalopride
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Prugen 2. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Prugen 2 during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Prugen 2 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Prugen 2 may cause side effects which could affect your ability to drive.
Prugen 2 may cause dizziness and tiredness, especially on the first day of treatment, and this may have an effect on driving and use of machines.
CAUTION
Prugen 2 should be used with caution in patients with severe kidney disease. Dose adjustment of Prugen 2 may be needed. Please consult your doctor.
CAUTION
Prugen 2 should be used with caution in patients with severe liver disease. Dose adjustment of Prugen 2 may be needed. Please consult your doctor.
Limited information is available on the use of Prugen 2 in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Prugen 2mg Tablet
Introduction
Prugen 2 is a prescription medicine used in the treatment of constipation. It increases the release of certain chemical that improves the movement of food inside the intestine and helps to increase gastric emptying of both liquid and solid. Prugen 2 is taken with or without food in a dose and duration as advised by the doctor. The dose you're given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition...
... Show moreUses of Prugen 2
- Constipation
Side effects of Prugen 2
Common
- Headache
- Nausea
- Diarrhea
- Abdominal pain
How to use Prugen 2
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prugen 2 may be taken with or without food, but it is better to take it at a fixed time.
How Prugen 2 works
Prugen 2 indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.
What if you forget to take Prugen 2?
If you miss a dose of Prugen 2, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Prugen 2 helps treat chronic constipation and improve bowel movements, when laxatives have failed to provide adequate relief.
- It can be taken with or without food, at any time of the day.
- It may cause diarrhea. Drink plenty of water and inform your doctor if it bothers you.
- Inform your doctor if your constipation has not improved even after four weeks of taking this medication.
Brief Description
Indication
Chronic idiopathic constipation.
Administration
May be taken with or without food.
Adult Dose
Oral
Chronic idiopathic constipation
Adult: 2 mg once daily.
Elderly: Initially, 1 mg once daily, may increase to 2 mg once daily if necessary.
Hepatic Impairment
Severe (Child-Pugh Class C): Initially, 1 mg once daily, may increase to 2 mg once daily if necessary.
Renal Dose
Severe (GFR <30 mL/min/1.73 m2): 1 mg once daily.
Patient on dialysis: Contraindicated.
Contraindication
Intestinal obstruction or perforation, obstructive ileus, active severe inflammatory bowel conditions (e.g. Crohn’s disease, toxic megacolon/megarectum, and ulcerative colitis). Renal impairment requiring dialysis. Pregnancy and lactation.
Mode of Action
Prucalopride is a selective 5-HT4 receptor agonist w/ prokinetic effect. It stimulates peristaltic reflex, intestinal secretions, and GI motility.
Precaution
Patient w/ history of arrhythmias or ischaemic CV disease, severe and unstable concomitant disease (e.g. cancer, AIDS, neurological or psychiatric, pulmonary, IDDM or other endocrine disroders). Severe hepatic (Child-Pugh Class C) and renal (GFR <30 mL/min/1.73 m2) impairment. Elderly.
This drug may cause dizziness and fatigue, if affected, do not drive or operate machinery.
Monitoring Parameters: Monitor bowel movement frequency.
Side Effect
Nervous: Headache, dizziness, fatigue, malaise, tremors.
CV: Palpitations.
GI: Nausea, abdominal pain and distention, diarrhoea, vomiting, flatulence, dyspepsia, anorexia, rectal bleeding, gastroenteritis.
Genitourinary: Polyuria, pollakiuria.
Musculoskeletal: Muscle spasm.
Others: Fever.
Interaction
May decrease serum concentration of contraceptives (i.e. oestrogens, progestins). May enhance adverse effect of levosulpiride. Increased serum concentration w/ P-glycoprotein/ABCB1 inhibitors. Reduced effect w/ atropine-like substance.
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