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Zoladex LA 10.8
MGH Healthcare Limited
Generic: Goserelin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Zoladex LA 10.8. Please consult your doctor.
UNSAFE
Zoladex LA 10.8 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Zoladex LA 10.8 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Zoladex LA 10.8 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Zoladex LA 10.8 is safe to use in patients with kidney disease. No dose adjustment of Zoladex LA 10.8 is recommended.
SAFE IF PRESCRIBED
Zoladex LA 10.8 is safe to use in patients with liver disease. No dose adjustment of Zoladex LA 10.8 is recommended.
Medicine Overview of Zoladex LA 10.8 10.8mg Injection
Introduction
Zoladex LA 10.8 is used for the treatment of prostate cancer in men and for breast cancer, endometriosis and uterine fibroids in women. In combination with some other medicine, it is used in the treatment of female infertility. Zoladex LA 10.8 is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in...
... Show moreUses of Zoladex LA 10.8
- Prostate cancer
- Breast cancer
- Endometriosis
- Uterine fibroids
- Female infertility
Side effects of Zoladex LA 10.8
Common
- Increased sweating
- Decreased libido
How to use Zoladex LA 10.8
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Zoladex LA 10.8 works
Zoladex LA 10.8 is a synthetic hormone. In men, it works by reducing the level of testosterone (male hormone) which causes regression of prostate tumor and improves symptoms. In women, it suppresses the level of estradiol (female hormone) which helps treat advanced breast cancer, endometriosis and uterine fibroids. It also reduces the thickness of the endometrium, which is the uterus lining, prior to surgery.
Quick Tips
- Zoladex LA 10.8 is used for the treatment of prostate cancer in men and for breast cancer, endometriosis, and uterine fibroids in women.
- It may also be used along with other medicines to treat infertility in women.
- It is a prefilled syringe that is injected under the skin of the abdomen, every 28 days.
- It may cause a reduction in bone mineral density and weakened bones. Your doctor may prescribe other medicines to reduce bone loss.
- Inform your doctor if you start to feel depressed or have disturbing thoughts or feelings during treatment with this medicine.
- Vaginal bleeding may occur in the first month after starting treatment and usually stops on its own. Inform your doctor if bleeding continues.
Brief Description
Indication
Palliative treatment of prostatic carcinoma, Pituitary desensitisation before ovulation induction with gonadotrophins, Breast Cancer, Endometriosis
Adult Dose
Subcutaneous
Palliative treatment of prostatic carcinoma
Adult: 3.6 mg injected into the anterior abdominal wall every 28 days or 10.8 mg every 12 wk. An anti-androgen is given several days before beginning of the treatment and continued for at least 3 wk to prevent disease flare.
Pituitary desensitisation before ovulation induction with gonadotrophins
Adult: 3.6 mg as a depot inj. Monitor serum-oestradiol concentrations until they decline to levels similar to those in the early follicular phase which takes about 7-21 days.
Contraindication
Hypersensitivity; pregnancy, lactation.
Mode of Action
Goserelin is a potent inhibitor of pituitary gonadotrophin secretion. Initially, it causes an increase in the serum levels of FSH and LH but chronic admin will lead to sustained suppression of the pituitary gonadotrophin release causing regression of the sex organs.
Precaution
Urinary tract obstruction or spinal cord compression (when used for prostate cancer); decreased bone density in women. Contraceptive measures should be taken to protect against pregnancy. Monitor men at risk from tumour flare during the 1st mth of therapy. Safety and efficacy on the usage of the 10.8 mg implant in women is not established.
Lactation: excretion in milk unknown; not recommended
Side Effect
>10%
Flushing (46-96%),Vaginitis (5-75%),Hot flashes (62%),Reduced libido (47-61%),Mood swings (60%),Depression (women 54%),Sweating (16-45%),Acne (42%),Diarrhea (40%),Breast atrophy (33%),Headache (women 32-75%),Seborrhea (26%),Tumor flare (23%),Sexual dysfunction (21%),Peripheral edema (21%),Erectile dysfunction (18%),Pain (8-17%),UTI (13%)
1-10%
Nausea (9%),Lethargy (8%),Rash (6%),Chronic obstructive pulmonary disease (5%),Congestive heart failure(5%),Cerebrovascular accident (1-5%),Renal impairment (1-5%),Headache (men 1-5%),Depression (men 1-5%),Immune hypersensitivity reaction (>1%)
Frequency Not Defined
Asthenia,Hypercalcemia,Cystitis,Dysmenorrhea,Hirsutism,Dyspareunia,Breast changes,Implant site reactions,Bone pain,Spinal cord compression (rare)
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