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Biva

Injection-(250mg/5ml)
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Healthcare Pharmaceuticals Ltd.

Generic: Bivalirudin

1 x 250mg Vial
৳ 9090
৳ 10000
9% OFF

Medicine Overview of Biva 250mg/5ml Injection

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Introduction

Biva belongs to a group of medicines known as an anticoagulant or blood thinner. It helps prevent and treat blood clots. It is used to reduce the risk of stroke and heart attack. It prevents and treats clot formation in the veins of your legs, lungs, brain and heart. Biva is commonly used in patients with irregular heart rhythm (atrial fibrillation) to prevent clot formation. It also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. It is given as an infusion (drip) into a vein under the supervision of a doctor. You may need to take this medicine for many years, even for life in some cases. Do not stop taking it or change the dose without guidance from your doctor. It could quickly put you at more risk of having a heart attack, stroke or thrombosis (formation of a blood clot within a blood vessel). You can reduce your risk of having a blood clot by making changes to your lifestyle, such as not smoking, eating a healthy diet, exercising regularly and losing weight if you need to. The most common side effect of Biva is bleeding more easily than normal, for example having nosebleeds or bruising. If you experience any symptoms, tell your doctor immediately. You should be extra careful while shaving, cutting nails, or using sharp objects during the treatment with this medicine. This medicine may not be suitable for everyone and should be used with caution. Inform your doctor, if you have severe kidney or liver problems. Do not take this medicine if you are currently bleeding or if you are taking other medicines to reduce blood clotting. You should not breastfeed while using this medicine. Unlike other anticoagulants, regular blood test (PT-INR) is not required while taking this medicine.

Uses of Biva

  • Heart attack
  • Unstable angina

Side effects of Biva

Common
  • Bruise

How to use Biva

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Biva works

Biva is an anticoagulant that prevents the formation of harmful blood clots.

Quick Tips

  • It is a hospital only medicine. It is given by your nurse or doctor as an infusion (drip) into a vein.
  • Notify your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood).
  • Inform your doctor if you are taking other blood thinners or medicines to prevent blood clots.

Brief Description

Indication

As an anticoagulant in percutaneous coronary intervention

Administration

IV Preparation To each 250 mg vial add 5 mL SWI Gently swirl until all material is dissolved Dilute each vial in 50 mL of D5W or NS to yield a final concentration of 5 mg/mL If low-rate infusion is used after initial infusion, a lower concentration bag should be prepared Inspect for particulate matter and discoloration prior to administration Do not use preparations containing particulate matter Reconstituted drug will be a clear to slightly opalescent, colorless to slightly yellow solution IV Administration Initial bolus injection followed by continuous infusion

Adult Dose

Intravenous As an anticoagulant in percutaneous coronary intervention Adult: Initially, 0.75 mg/kg inj followed by an infusion of 1.75 mg/kg/hr during procedure and up to 4 hours postprocedure. If needed, may continue infusion at 0.25 mg/kg/hr for 4-12 hours. Hepatic impairment: No dosage adjustment needed.

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation 30-59 Reduced infusion to 1.4 mg/kg/hr. <30 Contraindicated. Dialysis Contraindicated.

Contraindication

Active major bleeding. CrCl <30 mL/min and dialysis-dependent patients. Severe uncontrolled HTN; subacute bacterial endocarditis.

Mode of Action

Bivalirudin is a synthetic 20-amino acid analogue of the naturally occurring hirudin. It is a specific and reversible direct thrombin inhibitor thats works by binding to the catalytic and anionic exosite of circulating and clot-bound thrombin. It is used as an anticoagulant in percutaneous coronary intervention.

Precaution

Increased risk of potentially fatal thrombosis during brachytherapy procedure. Patients at high risk of serious bleeding; recent major surgery or puncture of large vessels or organ biopsy. Renal impairment. Pregnancy, lactation, elderly.

Side Effect

>10% Back pain (42%) General pain (15%) Nausea (15%) Hemorrhage, minor (13.6%) Headache (12%) Hypotension (12%) 1-10% Injection site pain (8%) Insomnia (7%) Pelvic pain (6%) Hypertension (6%) Anxiety (6%) Vomiting (6%) Bradycardia (5%) Dyspepsia (5%) Abdominal pain (5%) Fever (5%) Nervousness (5%) Urinary retention (4%) Hemorrhage, major (2.3%) >3g/dL fall in Hgb (1.9%) TIMI minor bleeding (1.3%) RBC transfusions (1.3%)

Pregnancy Category Note

Pregnancy There are no data available in pregnant women to inform a drug-associated risk of adverse developmental outcomes Animal data Reproduction studies in rats and rabbits administered subcutaneously doses up to 1.6 times and 3.2 times maximum recommended human dose (MRHD) of 15 mg/kg/day based on body surface area (BSA) during organogenesis, respectively, revealed no evidence of fetal harm Lactation Not known whether drug is present in human milk; no data are available on effects on breastfed child or on milk production; developmental and health benefits of breastfeeding should be considered along with clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition

Interaction

May increase risk of bleeding when used w/ thrombolytics, oral anticoagulants or drugs that affect platelet function.

Buy Biva from Arogga

In Bangladesh, you can get the original Biva. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Biva in Bangladesh?

The latest price of Biva in Bangladesh is 9090৳. You can buy Biva at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
It is unsafe to consume alcohol with Biva.
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SAFE IF PRESCRIBED
Biva is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
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CONSULT YOUR DOCTOR
Biva is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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NOT RELEVANT
Not relevant, as Biva is intended for use in hospitalised patients.
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CAUTION
Biva should be used with caution in patients with kidney disease. Dose adjustment of Biva may be needed. Please consult your doctor. Use of Biva is not recommended in patients with severe kidney disease and patients undergoing dialysis.
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SAFE IF PRESCRIBED
Biva is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Biva may not be needed in these patients. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.