12-24 Hours
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Caspogin
Healthcare Pharmaceuticals Ltd.
Generic: Caspofungin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Caspogin. Please consult your doctor.
CONSULT YOUR DOCTOR
Caspogin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Caspogin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Caspogin alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Caspogin is safe to use in patients with kidney disease. No dose adjustment of Caspogin is recommended.
CAUTION
Caspogin should be used with caution in patients with liver disease. Dose adjustment of Caspogin may be needed. Please consult your doctor.
Limited information is available on the use of Caspogin in patients with the severe liver disease.
Medicine Overview of Caspogin 70mg/vial Injection
Introduction
is an antifungal medication. It is used in the treatment of severe fungal infections. It kills the fungi that cause infections and thus provides relief. Caspogin is administered as an injection by a healthcare professional. Kindly do not self administer. Do not skip any doses and finish the full course of treatment even if you feel better. Your liver function should be monitored regularly during treatment. It may lead to a few common side effects like rash, decreased potassium level in blood, fever, increased liver enzymes, chills, and diarrhea. You may also notice some injection site reactions like pain, swelling...
... Show moreUses of Caspogin
- Severe fungal infections
Side effects of Caspogin
Common
- Chills
- Decreased potassium level in blood
- Diarrhea
- Fever
- Increased alkaline phospatase level in blood
- Increased liver enzymes
- Rash
How to use Caspogin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Caspogin works
Caspogin kills fungus by preventing them from making their protective covering.
What if you forget to take Caspogin?
If you miss a dose of Caspogin, please consult your doctor.
Quick Tips
- Caspogin is given as a slow drip into vein (IV infusion) under the supervision of a doctor.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Your doctor may check your liver function regularly. Inform your doctor if you develop abdominal pain, loss of appetite, darkened urine or yellowing of the eyes or skin (jaundice).
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Candidemia and other Candida infections including intra-abdominal abscesses, peritonitis, and pleural space infections, Esophageal Candidiasis, Invasive Aspergillosis, Febrile Neutropenia
Administration
IV Preparation Reconstitute vial (70 mg for loading dose or 50 mg for daily dose) with 10.5 mL NS, SWI or BWI-may be stored for up to 1 hr at 25°C (or less) Mix gently to obtain clear soln-discard if particulate or discolored Transfer 10 mL of reconstituted solution to 250 mL NS, 1/2NS 1/4NS or LR Use infusion soln within 24 hr if stored at room temp or within 48 hr if refrigerated at 2-8°C If 70 mg vials are not available for preparation of the loading dose, reconstitute two 50 mg vials & transfer 14 mL to 250...
... Show moreAdult Dose
Intravenous Candida Infections Includes candidemia and other Candida infections including intra-abdominal abscesses, peritonitis, and pleural space infections Day 1 loading dose: 70 mg IV infused over 1 hr (as a single dose) Maintenance: 50 mg IV qDay infused over 1 hr Continue antifungal therapy for at least 14 days after last positive culture; patients who remain persistently neutropenic may warrant longer course of therapy pending resolution of neutropenia Esophageal Candidiasis Indicated for treatment of esophageal candidiasis 50 mg IV qDay infused over 1 hr, continue for 7-14 days after symptom resolution Loading dose not necessary, has not been studied with...
... Show moreChild Dose
Candida Infections Includes candidemia and other Candida infections including intra-abdominal abscesses, peritonitis, and pleural space infections Dosing based on patient’s body surface area 3 months Day 1 loading dose: 70 mg/m² IV infused over 1 hr Maintenance: 50 mg/m² IV qDay infused over 1 hr If well tolerated but not achieving adequate response, may increase to 70 mg/m² IV qDay Not to exceed 70 mg qDay Continue antifungal therapy for at least 14 days after last positive culture; patients who remain persistently neutropenic may warrant longer course of therapy pending resolution of neutropenia Esophageal Candidiasis Dosing based on patient’s body...
... Show moreContraindication
Hypersensitivity.
Mode of Action
Caspofungin, a semisynthetic echinocandin antifungal, shows activity against Aspergillus and Candida species. It inhibits the synthesis of β-1,3-D-glucan, an essential component of the fungal cell wall that is not present in mammalian cells.
Precaution
Anaphylaxis reported, discontinue and administer appropriate treatment; possible histamine-mediated adverse reactions, including rash, facial swelling, angioedema, pruritus, sensation of warmth or bronchospasm
Hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor hepatic function.
Side Effect
>10%
Infused vein complications/ phlebitis (20-35%)
Fever (6-30%)
Diarrhea (6-27%)
Shivering (9-23%)
Rash (4-23%)
Incr serum alk phos (9-22%)
Hypotension (3-20%)
Respiratory failure (2-20%)
Incr transaminases (2-18%)
Septic shock (11% to 14% )
1-10% (selected)
Pleural effusion (9%)
Respiratory distress (up to 8%)
Abdominal pain
Nausea
Vomiting
Anemia
Decreased Hgb
Neutropenia
Chills
Hypokalemia
Dizziness
Erythema
Facial edema, flushing
Hematuria
Hyperbilirubinemia
Increased serum creatinine
Induration
Myalgia
Pain
Paresthesia
Pruritus
Sepsis
Tachycardia
<1%
Erythema multiforme
Stevens-Johnson syndrome
Pancreatitis
Hepatic necrosis
Liver failure
Anaphylaxis
Nephrotoxicity
Renal impairment
Pregnancy Category Note
Pregnancy There are insufficient human data to establish whether there is a drug-associated risk for major birth defects, miscarriage, or adverse maternal or fetal outcomes in pregnant women Animal data In animal studies, drug caused embryofetal toxicity, including increased resorptions, increased peri-implantation loss, and incomplete ossification at multiple fetal sites when administered intravenously to pregnant rats and rabbits during organogenesis at doses up to 0.8 and 2 times the clinical dose, respectively; advise patients of potential risk to fetus; estimated background risk of major birth defects and miscarriage for indicated population is unknown; all pregnancies have a background risk of...
... Show moreInteraction
Reduced plasma concentration w/ rifampicin and other CYP enzyme inducers. May increase hepatic enzymes w/ ciclosporin. May decrease blood concentration of tacrolimus.
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