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Diavix
Beximco Pharmaceuticals Ltd.
Generic: Lamivudine + Zidovudine
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Diavix. Please consult your doctor.
CONSULT YOUR DOCTOR
Diavix may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Diavix is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Diavix may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Diavix should be used with caution in patients with kidney disease. Dose adjustment of Diavix may be needed. Please consult your doctor.
CAUTION
Diavix should be used with caution in patients with liver disease. Dose adjustment of Diavix may be needed. Please consult your doctor.
Use of Diavix is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Diavix 150mg+300mg Tablet
Introduction
Diavix is a combination of two antiretrovirals. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). Diavix restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full...
... Show moreUses of Diavix
- HIV infection
Side effects of Diavix
Common
- Nausea
- Headache
- Diarrhea
- Fatigue
- Cough
- Feeling of discomfort
- Nasal congestion (stuffy nose)
How to use Diavix
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diavix may be taken with or without food, but it is better to take it at a fixed time.
How Diavix works
Diavix is a combination of two anti-HIV medicines: Lamivudine and Zidovudine. They prevent HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.
Quick Tips
- Diavix is a combination of two medicines which slows down or stops the progression of HIV infections.
- It may also be used for preventing HIV and should be started within 72 hours of exposure to HIV.
- Take it with food, as this increases the absorption of the medicine into the body.
- Diavix may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
- Always practice safe sex while taking Diavix. Do not share needles or personal items that can have blood or body fluids on them.
- It may cause weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
Brief Description
Indication
HIV infection
Administration
May be taken with or without food.
Adult Dose
Oral
HIV infection
Adult: Each tab contains lamivudine 150 mg and zidovudine 300 mg:
>30 kg: 1 tab bid.
Avoid administering to patients < 30 kg
Hepatic impairment: Severe: Not recommended, use separate preparations.
Child Dose
HIV Infection
12 years and 12 years and >30 kg: As adults; 150 mg/300 mg (1 tablet) PO q12hr
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<50 Not recommended, use separate preparations
Contraindication
Neutrophil count <0.75 x 109/l; haemoglobin levels <7.5 g/dl or 4.65 mmol/l. Lactation.
Mode of Action
Lamivudine: NRTI; following phosphorylation, inhibits HIV reverse transcriptase by viral DNA chain termination; cytosine analog
Zidovudine: NRTI; interferes with HIV viral RNA-dependent DNA polymerase (inhibits viral replication); thymidine analog
Precaution
Renal and hepatic impairment; poor bone marrow reserve prior to treatment; risk of opportunistic infection; patients (especially obese women) with risk factors for or active liver disease. Patients with low body wt should avoid the combined formulation. Separate formulations of lamivudine or zidovudine should not be given at the same time as the combined formulation. If dose adjustment is necessary for either component, separate formulations should be used. Monitor haematological parameters (advanced disease: 2 wkly for 1st 3 mth of treatment, then monthly; early disease: 1-3 mthly), LFTs, mean cell volume, serum creatinine kinase, viral load, CD4 counts and blood...
... Show moreSide Effect
>10%
Headache (35%),Nausea (33%),Malaise & fatigue (27%),Cough (18%),Diarrhea (18%),Vomiting (13%),Musculoskeletal pain (12%),Neuropathy (12%),Insomnia & other sleep disorders (11%)
1-10%
Anorexia &/or decreased appetite (10%),Dizziness (10%),Fever or chills (10%),Abdominal pain (9%),Depressive disorders (9%),Skin rashes (9%),Myalgia (8%),Neutropenia (7.2% ),Abdominal cramps (6%),Arthralgia (5%),Dyspepsia (5%),Anemia (2.9% )
Frequency Not Defined (serious)
Erythema multiforme,Stevens-Johnson syndrome,Lactic acidosis,Pancreatitis,Hepatomegaly (Severe),Steatosis of liver (Severe),Anaphylaxis,Immune hypersensitivity reaction,Rhabdomyolysis
Potentially Fatal: Lactic acidosis associated with liver failure and pancreatitis (normally after several mth of treatment); haematological toxicity (eg neutropenia and severe anaemia).
Interaction
Zidovudine: acyclovir and valacyclovir may increase CNS depression. Increased risk of haematologic toxicity with ganciclovir, valganciclovir, dapsone, doxorubicin, vincristine and vinblastine. Doxorubicin may reduce phophorylation; fluconazole may increase levels/effects; increased risk of hepatic decompensation or haematologic toxicities with interferon-? and ribavirin (also increases risk of pancreatitis and lactic acidosis). Methadone may increase effects/levels. Increased risk of myalgia, malaise and/or fever, maculopapular rash and effects/levels with probenecid. Stavudine may decrease antiviral activity; valproic acid may increase plasma levels (AUC increased by 80%). Lamivudine: Increased risk of hepatic decompensation or haematologic toxicities with interferon-? and ribavirin (also increases risk of mitochondrial toxicity,...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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