With a history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack (TIA)) (see WARNINGS). with inadequately controlled hypertension > 145/90 mm Hg (see WARNINGS). over 65 years of age. receiving monoamine oxidase inhibitors (MAOIs) (see WARNINGS). with hypersensitivity to sibutramine or any of the inactive ingredients of MERIDIA (sibutramine hydrochloride monohydrate) . who have a major eating disorder (anorexia nervosa or bulimia nervosa). taking other centrally acting weight loss drugs.