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Difitox
Al-Madina Pharmaceuticals Ltd.
Generic: Doxycycline
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Difitox.
CONSULT YOUR DOCTOR
Difitox is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Difitox is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Difitox may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Visual disturbances such as blurring of vision may occur during treatment with doxycycline.
SAFE IF PRESCRIBED
Difitox is safe to use in patients with kidney disease. No dose adjustment of Difitox is recommended.
However, talk to your doctor if you have any underlying kidney disease.
SAFE IF PRESCRIBED
Difitox is safe to use in patients with liver disease. No dose adjustment of Difitox is recommended.
Medicine Overview of Difitox 100mg Capsule
Introduction
Difitox is an antibiotic medicine used to treat bacterial infections in your body. It is effective in some infections of the lungs, urinary tract, eyes, and others. It kills bacteria, which helps to improve your symptoms and cure the infection. Difitox is also used to treat many sexually transmitted diseases and a skin condition known as acne. It should be taken preferably either one hour before or 2 hours after a meal. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you...
... Show moreUses of Difitox
- Bacterial infections
Side effects of Difitox
Common
- Vomiting
- Nausea
- Diarrhea
How to use Difitox
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Difitox is to be taken empty stomach.
Avoid Difitox with dairy products such as milk, cheese, curd, butter, paneer and ice cream.
How Difitox works
Difitox is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Quick Tips
- Your doctor has prescribed Difitox to cure your infection and improve symptoms.
- Take it with food and plenty of water to avoid stomach upset.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Take it while you are sitting or standing, to prevent any throat irritation. Do not lie down for at least 30 minutes after taking Difitox.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Avoid excessive sun exposure and use sunscreen and protective clothing when outdoors.
Brief Description
Indication
Acne, Susceptible infections, Syphilis, Uncomplicated gonorrhoea, Relapsing fever, louse-borne typhus, Scrub typhus
Administration
May be taken with or without food. Take w/ a full glass of water & remain upright for at least ½ hr. Take w/ food or milk if GI irritation occurs.
Adult Dose
Oral Susceptible infections Adult: 200 mg on day 1 as a single or in divided doses, followed by 100 mg once daily. Severe infections: Maintain initial dose throughout the course of treatment. Sexually Transmitted Diseases Uncomplicated gonococcal infection of the cervix, urethra, and rectum, Uncomplicated urethral, endocervical, or rectal infection caused by Chlamydia trachomatis, Nongonococcal urethritis caused by C. trachomatis and U. urealyticum 100 mg PO q12hr for 7 days Syphilis (early): Patients who are allergic to penicillin should be treated with doxycycline 100 mg PO BID x 2 weeks Syphilis >1 year duration: Patients who are allergic to penicillin...
... Show moreChild Dose
Children: PO >8 y, <45 kg: 2–4 mg/kg/day q12h
Contraindication
It is contraindicated to patients with known hypersensitivity to any of the tetracyclines. It is also contraindicated in severe hepatic disorder and patients with systemic lupas erythematosus. Concomitant intake of alkalis, antacids and iron may interfere with the absorption of Doxycycline. It is advisable to avoid giving doxycycline in conjunction with penicillin. Doxycycline should not be used in pregnant women unless, in the judgment of the physician, it is essential for the welfare of the patient.
Mode of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has bacteriostatic activity against a broad range of gm+ve and gm-ve bacteria.
Precaution
The use of drugs of tetracycline group during tooth development (last half of pregnancy, infancy and childhood to the age of 12 years) may cause permanent discoloration of the teeth. Tetracyclines, therefore, should not be used in this age group unless other drugs are not likely to be effective or are contraindicated.
Lactation: Enters breast milk; Not recommended
Side Effect
Hypotension, pericarditis, angioneurotic oedema, dyspnoea, serum sickness, peripheral oedema, tachycardia, urticaria, haemolytic anaemia, thrombocytopenia, neutropenia, porphyria, eosinophilia, brown-black microscopic discolouration of thyroid tissue, headache, bulging fontanelles in infants and benign intracranial HTN in adults, blurring of vision, scotomata, diplopia, tinnitus, abdominal pain, stomatitis, anorexia, nausea, vomiting, diarrhoea, dyspepsia, oesophageal ulceration, discolouration of teeth, enamel hypoplasia, transient increases in LFT and BUN, jaundice, pancreatitis, rashes, exfoliative dermatitis, photo-onycholysis, photosensitivity, arthralgia, myalgia, vaginitis.
Potentially Fatal: Anaphylactoid reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, Clostridium difficile-associated disease (CDAD), hepatotoxicity.
Pregnancy Category Note
Pregnancy Not studied in pregnant patients; the vast majority of reported experience with doxycycline during human pregnancy is short-term, first trimester exposure; there are no human data available to assess effects of long-term therapy of doxycycline in pregnant women, such as that proposed for treatment of anthrax exposure; it should not be used in pregnant women unless, in judgment of physician, it is essential for welfare of patient; evidence of embryotoxicity has been noted in animals treated early in pregnancy Lactation Tetracyclines are excreted in human milk; however, extent of absorption of tetracyclines, including doxycycline, by breastfed infant is not...
... Show moreInteraction
Concomitant use w/ isotretinoin is known to cause pseudotumour cerebri. Prolonged prothrombin time w/ anticoagulants (e.g. warfarin). May interfere w/ the bactericidal action of penicillin. Impaired absorption w/ antacids containing Al, Ca, or Mg, oral Zn, Fe salts, and bismuth preparations. Increased metabolism w/ phenobarbital, carbamazepine, primidone and phenytoin. Risk of breakthrough bleeding w/ oral contraceptives. Increased plasma concentration of ciclosporin. Decreased half-life w/ hepatic enzymes inducers (e.g. rifampicin).
Potentially Fatal: Concurrent use w/ methoxyflurane may result to fatal renal toxicity.
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