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Disys PLUS
Healthcare Pharmaceuticals Ltd.
Generic: Hydrochlorothiazide + Valsartan
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Disys PLUS.
CONSULT YOUR DOCTOR
Disys PLUS is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Disys PLUS is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Disys PLUS may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Disys PLUS should be used with caution in patients with severe kidney disease. Dose adjustment of Disys PLUS may be needed. Please consult your doctor.
Use of Disys PLUS is not recommended in patients with severe kidney disease.
CAUTION
Disys PLUS should be used with caution in patients with liver disease. Dose adjustment of Disys PLUS may be needed. Please consult your doctor.
Medicine Overview of Disys PLUS 12.5mg+80mg Tablet
Introduction
Disys PLUS is a combination of two medicines. It helps to control high blood pressure in different ways. If high blood pressure is not treated it can lead to heart attacks, strokes and kidney failure. You can take Disys PLUS with or without food. The dose will depend on your condition and how your respond to the medicine. Try to take it at the same time each day. It is important to keep taking this medicine until your doctor tells you not to. It contains a diuretic (water pill) and will make you urinate more so, it is best to...
... Show moreUses of Disys PLUS
- Hypertension (high blood pressure)
Side effects of Disys PLUS
Common
- Nausea
- Taste change
- Diarrhea
- Upset stomach
- Dizziness
- Decreased blood pressure
- Headache
- Fatigue
- Increased blood lipid level
- Electrolyte imbalance
- Increased blood uric acid
- Glucose intolerance
How to use Disys PLUS
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Disys PLUS may be taken with or without food, but it is better to take it at a fixed time.
How Disys PLUS works
Disys PLUS is a combination of two medicines: Valsartan and hydrochlorothiazide which lower blood pressure effectively. Valsartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- You have been prescribed Disys PLUS for the treatment of high blood pressure.
- It can be taken with or without food.
- Disys PLUS may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Use of Disys PLUS during pregnancy or breastfeeding is unsafe.
- It may also decrease the risk of stroke and heart attacks.
Brief Description
Indication
Hypertension, Diabetic nephropathy
Adult Dose
Hypertension
1 tablet/day PO (80-160 mg valsartan/12.5-25 mg hydrochlorothiazide); may be titrated after 1-2 weeks of therapy; not to exceed 320 mg valsartan/25 mg hydrochlorothiazide daily
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Not recommended.
Contraindication
Hypersensitivity to valsartan, hydrochlorothiazide or sulphonamides. Severe hepatic impairment, creatinine clearance <30ml/min, anuria, cirrhosis, biliary obstruction, conditions where there is increased potassium loss (e.g. salt losing nephropathies and pre-renal impairment of kidney function), refractory hypokalaemia, hyponatraemia, hypercalcaemia, hyperuricaemia, history of gout and uric acid stones, untreated Addison's disease. Pregnancy and lactation.
Mode of Action
Valsartan is an angiotensin II receptor antagonist and reduces blood pressure by blocking the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Hydrochlorothiazide is a thiazide diuretic.
Precaution
DM, postsympathectomy patients. May exacerbate SLE. Monitor serum potassium regularly. Observe for signs of fluid or electrolyte imbalance. Discontinue before testing for parathyroid function. May affect ability to drive or operate machinery. Elderly.
Lactation: Discontinue drug, or do not nurse
Side Effect
1-10%
Valsartan
Hyperkalemia (4-10%),Dizziness (2-8%),Hypotension (1-7%),Fatigue (3%)
Frequency Not Defined
Hydrochlorothiazide
Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia
Pregnancy Category Note
Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D
Interaction
Increased antihypertensive effect with other antihypertensive drugs. Monitor potassium frequently if used with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or drugs that may affect potassium levels (e.g. heparin, ciclosporin, drospirenone, amphotericin, corticosteroids, carbenoxolone). Reduced antihypertensive effect of valsartan and increased risk of renal impairment with NSAIDs. May reduce renal clearance of cytotoxic drugs (e.g. cyclophosphamide, methotrexate). Increased serum calcium with vitamin D or calcium salts.
Potentially Fatal: Increased lithium levels with valsartan, monitor lithium levels. Increased risk of cardiac arrhythmia with dofetilide, avoid use.
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