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Dobixin 50
Drug International Ltd.
Generic: Doxorubicin Hydrochloride
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Dobixin 50. Please consult your doctor.
CONSULT YOUR DOCTOR
Dobixin 50 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Dobixin 50 during breastfeeding is not available. Please consult your doctor.
UNSAFE
Dobixin 50 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Dobixin 50 is safe to use in patients with kidney disease. No dose adjustment of Dobixin 50 is recommended.
Caution is advised in patients with severe kidney disease as the information available is limited for use of this medicine in these patients.
CAUTION
Dobixin 50 should be used with caution in patients with liver disease. Dose adjustment of Dobixin 50 may be needed. Please consult your doctor.
Use of Dobixin 50 is not recommended in patients with severe liver disease.
Medicine Overview of Dobixin 50 2mg/ml Injection
Introduction
Dobixin 50 is used in the treatment of some kinds of cancer. It is also used in the treatment of breast cancer, where there is an increased cardiac risk. It can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy. Dobixin 50 can be used in both adults and children. It is given as injection into vein with extreme caution by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for...
... Show moreUses of Dobixin 50
- Cancer
Side effects of Dobixin 50
Common
- Nausea
- Vomiting
- Rash
- Weakness
- Low blood platelets
- Fatigue
- Fever
- Decreased white blood cell count (neutrophils)
- Loss of appetite
- Anemia (low number of red blood cells)
- Constipation
- Stomatitis (Inflammation of the mouth)
- Diarrhea
- Painful blisters on hands and feet
How to use Dobixin 50
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Dobixin 50 works
Dobixin 50 is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Quick Tips
- Dobixin 50 helps treat cancer of the breast, blood, and ovaries.
- It is given through a drip into a vein (intravenous infusion) by a doctor or nurse.
- It may make you feel tired or sleepy. Do not drive or do anything that requires mental focus until you know how it affects you.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for 6 months after stopping treatment.
- Inform your doctor if you notice sores, discolouration or any discomfort in your mouth.
- Your doctor may get regular blood tests done to monitor your blood cells, liver, and heart function during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Brief Description
Indication
AIDS-related Kaposi's sarcoma, Ovarian carcinoma, Metastatic breast carcinoma, bladder carcinoma
Adult Dose
Intravenous As Doxorubicin liposomal Kaposi's Sarcoma Indicated for AIDS-related Kaposi’s sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy 20 mg/m² IV q3Weeks Ovarian Cancer Indicated for ovarian cancer in patients whose disease has progressed or recurred after platinum-based chemotherapy 50 mg/m² IV q4Weeks x 4 courses minimum Multiple Myeloma Indicated in combination with bortezomib for multiple myeloma in patients who have not previously received bortezomib and have received at least 1 prior therapy 30 mg/m² IV on day 4 following bortezomib 1.3 mg/m² on days 1, 4, 8 & 11 q3Weeks Metastatic breast cancer...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal Impairment
Dose adjustment not necessary
Contraindication
Cardiac disease, neonates, pregnancy and lactation, prior irradiation to mediastinum. IM/SC admin. Severe myelosuppression due to previous treatment with antitumour agents or radiotherapy.
Mode of Action
Doxorubicin is a cytotoxic anthracycline antibiotic. The cytotoxic action results from its binding to DNA and inhibition of nucleic acid synthesis. Doxorubicin has been shown to produce regression in a variety of disseminated malignancies.
Precaution
Elderly, children, hepatic impairment. Monitor blood counts and ECG.
Lactation: Enters breast milk/not recommended
Side Effect
>10%
Kaposi's Sarcoma
Anemia (>50%),Thrombocytopenia (>50%),Neutropenia (10-50%),Anemia (18.2%),Nausea (17%)
Ovarian cancer
>25%
Hand-foot syndrome (50%),Nausea (46%),Stomatitis (41%),Asthenia (40.2%),Vomiting (32.6%),Rash (28%),Constipation (>25%),Abdominal pain (>25%)
Ovarian cancer
10-25%
Fever (21.3%),Anorexia (20%),Diarrhea (20%),Peripheral edema,Dyspepsia,Pharyngitis,Dyspnea,Alopecia
1-10%
Kaposi's Sarcoma
5-10%
Asthenia (9.9%),Fever (9.1%),Diarrhea (7.8%),Vomiting (7.8%),Stomatitis (6.8%),Rash (1-5%),Alopecia (1-5%),Increased alkaline phosphatase
Kaposi's Sarcoma
1-5%
Hand-foot syndrome (3.4%),Hypotension,Tachycardia,Dyspnea,Hemolysis,Rash
Ovarian cancer (selected)
Neutropenia (13.3%),Anemia (0.4-5.4%),Thrombocytopenia (1.3%)
<1%
Abscess,Acute myeloid leukemia,Cardiomegaly,Cardiomyopathy,Erythema nodosum,Hyperkalemia,Hyperuricemia,Ketosis
Potentially Fatal: Bone marrow suppression, cardiotoxicity.
Pregnancy Category Note
Pregnancy Category: D
Lactation: Enters breast milk/not recommended
Interaction
Doxorubicin interacts with a number of other drugs e.g. antibiotics (aminoglycosides), steroids, aminophylline and propranolol.
Potentially Fatal: Cholestasis induced by mercaptopurine may be potentiated by concurrent administration of the drug. Toxicity may be increased if streptozocin is given concurrently.
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