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Doripen
Eskayef Pharmaceuticals Ltd.
Generic: Doripenem
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Doripen does not cause any harmful side effects.
SAFE IF PRESCRIBED
Doripen is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Doripen is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CONSULT YOUR DOCTOR
It is not known whether Doripen alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Doripen should be used with caution in patients with kidney disease. Dose adjustment of Doripen may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Doripen is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Doripen may not be needed in these patients. Please consult your doctor.
Medicine Overview of Doripen 500mg/vial Injection
Introduction
Doripen is an antibiotic belonging to the carbapenem group that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (eg. meningitis). It works by killing the bacteria that cause these problems. Doripen is commonly used to treat seriously ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections...
... Show moreUses of Doripen
- Severe bacterial infections
Side effects of Doripen
Common
- Vomiting
- Nausea
- Injection site reactions (pain, swelling, redness)
How to use Doripen
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Doripen works
Doripen is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Doripen?
If you miss a dose of Doripen, please consult your doctor.
Quick Tips
- Doripen is an antibiotic that's usually only given in the hospital for serious infections.
- It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes. In severe cases, it may be given slowly for 3 to 4 hours by intravenous infusion.
- Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication.
- Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools.
- Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
Brief Description
Indication
Intra-abdominal infections, Bacterial infections, Septicemia, Nosocomial pneumonia, Urinary tract infections, Pyelonephritis
Administration
Reconstitution:
Reconstitute 500 mg vial w/ 10 mL of sterile water for inj or NaCl 0.9% inj to form a susp containing 50 mg/mL. Further dilute the reconstituted vial w/ 100 mL of NaCl 0.9% or dextrose 5% inj, gently shake until clear. For a 250 mg dose, contents of the reconstituted vial should be withdrawn and added to 100 mL NaCl 0.9% infusion bag or dextrose 5% inj. Remove and discard 55 mL from the infusion bag to leave the remaining soln.
IV Administration
Infuse over 1 hr
Adult Dose
Intravenous
Complicated intra-abdominal infections
Adult: 500 mg 8 hrly infused over 1 hr for 5-14 days. May switch to an appropriate oral therapy, after at least 3 days of parenteral therapy upon evidence of clinical improvement.
Complicated urinary tract infections; Pyelonephritis
Adult: 500 mg 8 hrly infused over 1 hr for 10 days. May switch to an appropriate oral therapy, after at least 3 days of parenteral therapy upon evidence of clinical improvement. Duration can be extended up to 14 days for patients w/ concurrent bacteraemia.
Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment:
CrCl (ml/min)
30-50 250 mg every 8 hr by IV infusion over 1 hr
11-29 250 mg every 12 hr by IV infusion over 1 hr
Contraindication
Hypersensitivity; anaphylactic reactions to beta-lactams.
Mode of Action
Doripenem is a broad-spectrum carbapenem with potent in vitro antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria including Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins; which in turn inhibits the final transpeptidase step of peptidoglycan synthesis in bacterial cell walls.
Precaution
May decrease serum concentration of valproic acid to below therapeutic range thus increasing risk of breakthrough seizure; consider alternative antimicrobial agents or additional anti-seizure medications if concurrent usage is necessary. Prolonged use may result in Clostridium difficile-associated diarrhoea (CDAD). May cause development of drug-resistant bacteria when used in the absence of proven or strongly suspected bacterial infection. Renal impairment. Safety and efficacy have not been established in patients <18 yr old.
Lactation: unknown if excreted in breast milk; use caution
Side Effect
>10%
Headache (4-16%),Nausea (4-12%),Diarrhea (6-11%)
1-10%
Anemia (2-10%),Phlebitis (4-8%),Rash (1-5%),Pruritus (3%),Transaminases elevated (1-2%),Oral candidiasis (1%),Renal impairment/failure (1%)
Potentially Fatal: Anaphylaxis, toxic epidermal necrolysis, Stevens-Johnson Syndrome, interstitial pneumonia, seizure.
Pregnancy Category Note
Pregnancy Category: B
Lactation: unknown if excreted in breast milk; use caution
Interaction
Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.
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