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Docefrez
Healthcare Pharmaceuticals Ltd.
Generic: Docetaxel
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Docefrez.
CONSULT YOUR DOCTOR
Docefrez is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Docefrez is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
CONSULT YOUR DOCTOR
It is not known whether Docefrez alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
SAFE IF PRESCRIBED
Docefrez is safe to use in patients with kidney disease. No dose adjustment of Docefrez is recommended.
CAUTION
Docefrez should be used with caution in patients with liver disease. Dose adjustment of Docefrez may be needed. Please consult your doctor.
Medicine Overview of Docefrez 20mg/Vial Injection
Introduction
Docefrez is an anti-cancer medication used for the treatment of breast cancer, non-small cell lung cancer, prostate cancer and cancers of head and neck. It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or...
... Show moreUses of Docefrez
- Breast cancer
- Non-small cell lung cancer
- Prostate cancer
- Cancer of head and neck
Side effects of Docefrez
Common
- Breathlessness
- Constipation
- Edema (swelling)
- Infection
- Loss of appetite
- Muscle pain
- Nail disorder
- Pain
- Weakness
How to use Docefrez
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Docefrez works
Docefrez is an anticancer medication. It works by interfering with the microtubule structures which help the cancer cells to divide and multiply. This slows the growth of cancer cells and eventually kills them.
Quick Tips
- Docefrez is an anti-cancer medication used for the treatment of breast cancer, non-small cell lung cancer, prostate cancer and cancers of head and neck.
- Do not take Docefrez if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells and liver function during treatment with this medicine.
- It may cause side effects such as swelling of hands, lips, and weight gain. To reduce these side effects your doctor may suggest some medication along with this medicine called Corticosteroids.
- Inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever) or other signs of infection.
Brief Description
Indication
Breast cancer, Lung cancer, Prostate cancer, Stomach cancer, Head/neck cancer
Administration
IV Preparation Dual vial formulation Requires 2-step dilution Reconstitute vial contents (20 mg/0.5 mL or 80 mg/2 mL) with supplied diluent (13% (w/w) ethanol/water) to obtain a 10 mg/mL solution Further dilute with NS or D5W to a final concentration of 0.3-0.74 mg/mL and prepare in a glass bottle, polypropylene, or polyolefin plastic bag to prevent leaching of plasticizers Use within 4 hr (including the 1 hr infusion) Single vial formulation Requires 1-step dilution Available as 20 mg/mL solution; further dilute with NS or D5W to a final concentration of 0.3-0.74 mg/mL and prepare in a glass bottle, polypropylene, or...
... Show moreAdult Dose
Intravenous Breast cancer Adult: 60-100 mg/m2 by infusion over 1 hr once every 3 wk. In combination w/ doxorubicin or capecitabine or as adjuvant therapy w/ doxorubicin and cyclophosphamide: 75 mg/m2 once every 3 wk. In combination w/ trastuzumab: 100 mg/m2 once every 3 wk. Hepatic impairment: Mild to moderate: Reduce dose from 100 mg/m2 to 75 mg/m2. Severe: Avoid use. Intravenous Head and neck cancer; Prostate cancer ; Non-small cell lung cancer; Gastric adenocarcinoma Adult: 75 mg/m2 by infusion over 1 hr once every 3 wk. For gastric adenocarcinoma: Dose is given before cisplatin and fluorouracil. For head and...
... Show moreRenal Dose
Renal Impairment
Dose adjustment not necessary
Contraindication
Previous severe hypersensitivity reaction to docetaxel, the solvent or polysorbate 80. Severe neutropenia; pregnancy, severe liver impairment.
Mode of Action
Docetaxel disrupts the microtubular network in cells that is essential for vital mitotic and interphase cellular functions. It binds to the free tubulin and promotes the assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly, resulting in inhibition of mitosis.
Precaution
Lactation. Hepatic impairment. Monitor liver blood function and blood counts regularly. Premedication with oral dexamethsaone at 16 mg daily for 3 days, starting one day before docetaxel treatment is recommended.
Lactation: Not known if excreted in breast milk, do not nurse
Side Effect
>50%
Alopecia,Anemia,Leukopenia,Neutropenia,Asthenia
10-50%
Fever,Infections,Fluid retention,Hypersensitivity,Skin reactions,Diarrhea,Nausea,Vomiting,Sensory neuropathy,Myalgia,Nail changes
1-10%
Arthralgia,Thrombocytopenia
Potentially Fatal: Neutropenia; fluid retention syndrome; anaemia.
Pregnancy Category Note
Pregnancy Based on findings in animal reproduction studies and its mechanism of action, therapy can cause fetal harm when administered to a pregnant woman; limited available human data are not sufficient to inform drug-associated risk during pregnancy Verify the pregnancy status of females of reproductive potential prior to initiating therapy Contraception Females of reproductive potential: Use effective contraception during treatment and for 6 months following last dose Males with female partners of reproductive potential: Use effective contraception during treatment and for 3 months following last dose Infertility Based on findings in animal studies, therapy may impair fertility in males of...
... Show moreInteraction
CYP3A4 inducers, inhibitors, or substrates may alter docetaxel metabolism.
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