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Irinotesin

Name: Irinotesin Irinotecan Hydrochloride Trihydrate Injection 20mg/ml
Brand: BOTS Pvt. Limited
SKU: 62266
Price: 7119.49 BDT
Availability: OutOfStock
Rating: 4.8 (1 reviews)

Injection-(20mg/ml)

BOTS Pvt. Limited

Generic: Irinotecan Hydrochloride Trihydrate

1 x 100mg Vial

৳ 7119.49

৳ 7420

4% OFF

Alternative Brands For Irinotesin

Medicine Overview of Irinotesin 20mg/ml Injection

বাংলা

Introduction

Irinotesin is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Irinotesin is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include fatigue, nausea, vomiting, weakness, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Irinotesin

Cancer of colon and rectum

Side effects of Irinotesin

Common

Fatigue
Nausea
Vomiting
Weakness
Hair loss
Fever
Anemia (low number of red blood cells)
Diarrhea
Decreased white blood cell count (neutrophils)
Decreased appetite
Mucosal inflammation

How to use Irinotesin

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Irinotesin works

Irinotesin is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

What if you forget to take Irinotesin?

If you miss a dose of Irinotesin, please consult your doctor.

Quick Tips

Irinotesin is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.

It is given via a drip into a vein (intravenous infusion).

It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.

Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.

Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.

Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.

Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.

Brief Description

Indication

Carcinoma of the colon or rectum

Administration

Reconstitution: Dilute in 5% dextrose injection (preferred) or 0.9% sodium chloride injection to a final concentration of 0.12-2.8 mg/ml.

Adult Dose

Intravenous Colorectal Cancer Indicated as first-line therapy (with 5-fluorouracil and leucovorin) for metastatic colorectal cancer (CRC); it is also indicated for CRC that has recurred or progressed following intial fluorouracil-based therapy Monotherapy Patients should be premedicated with antiemetic agents Atropine treatment should be considered in patients that experience cholinergic symptoms Regimen 1 (Weekly): 125 mg/m² IV infusion over 90 minutes on days 1, 8, 15, 22, then 2 weeks off, then repeat Regimen 2 (Once Every 3 Weeks): 350 mg/sq.meter IV infusion over 30-90 minutes q3Weeks Adjust dose per protocol Combination therapy Patients should be premedicated with antiemetic agents Atropine treatment should be considered in patients that experience cholinergic symptoms Regimen 1 (6 week cycle with infusional 5-fluorouracil/ leucovorin): 180 mg/m² IV infusion over 30-90 minutes once on days 1, 15, and 29 IV (infuse over 30-90 min), followed by infusion with leucovorin and 5-fluorouracil; next cycle begins on day 43 Regimen 2 (6 week cycle with bolus 5-fluorouracil/ leucovorin): 125 mg/sq.meter on days 1, 8, 15, and 22 (infuse over 90 min), followed by bolus doses of leucovorin and 5-fluorouracil Adjust dose per protocol Hepatic impairment: Dose reduction may be necessary.

Child Dose

Not recommended

Contraindication

Patients with a known hypersensitivity to the drug or its excipients.

Mode of Action

Irinotecan, a derivative of camptothecin, works by inhibiting the enzyme topoisomerase I thereby interfering with the coiling and uncoiling of DNA during replication and causing irreparable damage.

Precaution

Early diarrhea is usually transient and infrequently severe. It may be accompanied by cholinergic symptoms of rhinitis, increased salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis that can cause abdominal cramping. Bradycardia may also occur. Late diarrhea can be life threatening since it may be prolonged and may lead to dehydration, electrolyte imbalance, or sepsis.Late diarrhea can be complicated by colitis, ulceration, bleeding, ileus, obstruction, and infection. Cases of megacolon and intestinal perforation have been reported. Lactation: not known if excreted in breast milk, do not nurse

Side Effect

>10% Anemia (>90%),Leukopenia (>90%),Neutropenia (>90%),Thrombocytopenia (>90%),Elevated bilirubin (88%),Diarrhea (85%),Nausea (79%),Asthenia (70%),Abdominal pain (63%),Vomiting (60%),Alopecia (43%),Fever (42%),Constipation (41%),Anorexia (34%),Mucositis (32%),Pain (31%),Dyspnea (28%),Cough (27%),Dizziness (23%),Infection (22%),Rash (19%) 1-10% Abdominal fullness (10%),AST increased (10%),Dyspepsia (10%),,Edema (10%),Ascites/jaundice (9%),Vasodilation (9%),Thromboembolism (9%),Hypotension (6%),Neutropenic fever (2-6%) Frequency Not Defined Headache,Insomnia,Orthostatic hypotension Potentially Fatal: Fatal sepsis due to myelosuppression; severe, chronic diarrhoea.

Interaction

Diuretics increase risks of dehydration secondary to vomiting/diarrhoea; prophylactic dexamethasone as an antiemetic may enhance lymphocytopenia; prochlorperazine may increase incidence of akathisia; antineoplastic agents (myelosuppression and diarrhoea). St John's wort, ketoconazole may reduce irinotecan exposure.

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What is the price of Irinotesin in Bangladesh?

The latest price of Irinotesin in Bangladesh is 7119.49৳. You can buy Irinotesin at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Irinotesin. Please consult your doctor.

CONSULT YOUR DOCTOR

Irinotesin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

UNSAFE

Irinotesin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

UNSAFE

Irinotesin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

SAFE IF PRESCRIBED

Irinotesin is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Irinotesin may not be needed in these patients. Please consult your doctor. Use of this medicine is not recommended for patients on dialysis.