Introduction
Edopain ER 600 is a pain relieving medicine. It effectively alleviates pain and inflammation in conditions like rheumatoid arthritis, osteoarthritis and acute pain.
Edopain ER 600 should be taken in the dose and duration as advised by your doctor. It should be taken with food or milk to prevent stomach upset. Inform your doctor if you have any history of heart disease or stroke.
Vomiting, stomach pain, nausea and indigestion are some of the common side effects that might be observed on taking this medicine. It may also cause dizziness, drowsiness or visual disturbances. Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
Side effects of Edopain ER 600
Common
- Vomiting
- Stomach pain/epigastric pain
- Nausea
- Indigestion
- Loss of appetite
- Diarrhea
- Heartburn
How to use Edopain ER 600
Use it as advised by your doctor or check the label for directions before use. Edopain ER 600 is to be taken with food.
How Edopain ER 600 works
Edopain ER 600 is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
Indication
Rheumatoid arthritis, Pain, Osetoarthritis
Administration
Should be taken with food. Take w/ or immediately after meals.
Adult Dose
Oral
Osteoarthritis; Rheumatoid arthritis
Adult: 600-1000 mg/day in divided doses adjusted according to response. Max: 1200 mg/day.
ER tablet: Once daily
Hepatic impairment: Dose adjustment not necessary
Child Dose
Juvenile Rheumatoid Arthritis
<6 years
Safety and efficacy not established
6-16 years
20-30 kg (extended release): 400 mg PO once daily
31-45 kg (extended release): 600 mg PO once daily
46-60 kg (extended release): 800 mg PO once daily
>60 kg (extended release): 1000 mg PO once daily
Renal Dose
Mild-to-moderate renal impairment: Dose adjustment not necessary
Severe renal impairment; Not recommended
Contraindication
Peptic ulcer, hypersensitivity to etodolac/NSAIDs. Childn; pregnancy (3rd trimester) and lactation.
Mode of Action
Etodolac is an NSAID derived from pyrano-indoleacetic acid, inhibits cyclooxygenase 2 (COX-2) resulting in decreased prostaglandin precursor formation.
Precaution
CHF, dehydration, impaired renal, hepatic function, history of GI disease. Elderly, patients receiving anticoagulant.
Lactation: Unknown whether drug is excreted in breast milk; not recommended
Side Effect
1-10%
Dyspepsia (10%),Dizziness (3-9%),Nervousness (1-3%),Pruritus (1-3%),Blurred vision (1-3%),Depression (1-3%),Chills/fever (1-3%)
>1%
Asthenia, malaise,Blurred vision,Bronchospasm,Dysuria, urinary frequency,Edema,Melena,Rash,Tinnitus
Potentially Fatal: Acute renal failure; blood disorder; nephrotoxicity; angioedema, arrhythmia, bone marrow suppression, CHF, dyspnoea, erythema multiforme, exfoliative dermatitis, hepatitis, hypertension, peripheral neuropathy, Stevens-Johnson syndrome, syncope, tachycardia, toxic amblyopia, toxic epidermal necrolysis, urticaria.
Pregnancy Category Note
Pregnancy category: C; avoid in late pregnancy (may cause premature closure of ductus arteriosus)
Lactation: Unknown whether drug is excreted in breast milk; not recommended
Interaction
Increased effect of warfarin, lithium, methotrexate, digoxin, cyclosporin, aspirin. Effect may be reduced with aspirin. Reduced effect of some diuretics and ?-blockers. Alcohol enhances gastric mucosal irritation.