Significant: QT interval prolongation, ventricular arrhythmias (including Torsade de pointes), cutaneous ischaemia and necrosis.
Cardiac disorders: Tachycardia, bradycardia, pulmonary oedema, dyspnoea.
Gastrointestinal disorders: Intestinal ischaemia, abdominal cramps, diarrhea, nausea, vomiting.
Metabolism and nutrition disorders: Rarely, hyponatraemia, hyperglycaemia.
Nervous system disorders: Convulsion, headache.
Reproductive system and breast disorders: Uterine ischaemia.
Respiratory, thoracic and mediastinal disorders: Bronchospasm, respiratory failure.
Vascular disorders: Hypertension, hypotension, pallor.