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Bio-Thistle
Jomjom Traders
Generic: Silymarin [Milk thistle]
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Bio-Thistle.
CONSULT YOUR DOCTOR
Bio-Thistle is not recommended for use during pregnancy. Controlled, long-term safety studies are lacking. Please consult your doctor.
CONSULT YOUR DOCTOR
No experience is available about the use of Bio-Thistle .Long-term safety studies are lacking. Please consult your doctor.
SAFE IF PRESCRIBED
Limited research on the effects of Bio-Thistle on driving ability.
CAUTION
It should be used with caution in patients with kidney disease. Dose adjustment of Bio-Thistle may be needed. Please consult your doctor.
CAUTION
It should be used with caution in patients with liver disease. Dose adjustment of Bio-Thistle may be needed. Please consult your doctor.
Medicine Overview of Bio-Thistle 500mg capsule
Introduction
Bio-Thistle is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Bio-Thistle exhibits hepatoprotective and regenerative properties and is one of the most widely used natural compounds for the treatment of hepatic diseases worldwide, due to its antioxidant, anti-inflammatory, and antifibrotic activities. Bio-Thistle also increases hepatic levels of glutathione by raising cysteine availability, while inhibiting its catabolism to taurine that may enhance the antioxidant defense in liver. Bio-Thistle was found to oppose oxidative stress, and to slow the progression of hepatic fibrosis in alcohol-fed baboons.
Uses of Bio-Thistle
Bio-Thistle is used for the treatment of Jaundice,chronic inflammatory liver conditions, hepatic cirrhosis ,alcoholic liver damage.
Side effects of Bio-Thistle
Sometimes it cause
- Mild digestive upset
- Allergic reactions
How to use Bio-Thistle
Take Bio-Thistle in the dose and duration as advised by your doctor. Take Bio-Thistle orally with plenty of water. Do not chew, crush or break it.
How Bio-Thistle work
Different mechanisms of action of Bio-Thistle are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as Bio-Thistle has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of Bio-Thistle is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake...
... Show moreWhat if you forget to take Bio-Thistle
If you forget to take yourBio-Thistle , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.
Brief Description
Indication
It is used for the treatment and prevention of-
Liver disease, (non-alcoholic & alcoholic) ,
Liver cirrhosis, (non-alcoholic & alcoholic)
Infectious hepatitis,
Drug-induced hepatitis,
Liver disease secondary to diabetes mellitus,
Toxicity of narcotics,
Fatty liver,
Jaundice.
Administration
Administered only orally as advised by the physician.
Adult Dose
1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician.
Child Dose
It should not be given to children without advice of physician. Uses for below 12 years recommended after discussion
with registered physician.
Renal Dose
It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor.
Contraindication
Contraindicated in patient with a known hypersensitivity to silymarin.
Mode of Action
Different mechanisms of action of silymarin are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as silymarin has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of silymarin is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake...
... Show morePrecaution
Over doses may mildly elevate blood pressure. Safety in young children or individuals with severe hepatic or renal disease is not known.
Side Effect
Occasionally a mild laxative effect may observe. Well tolerated in the recommended dose.
Pregnancy & Lactation Category Note
Therefore, if needed Silymarin should be taken with caution according to the physician’s advice. No established evidence is available about the use of Silymarin during pregnancy and lactation.
Interaction
Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation.
Storage Condition
Store in a cool & dry place, away from light & moisture. Keep out of reach of children.
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