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Vonocab Trio

tablet-(20mg+500mg+500mg)
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Beximco Pharmaceuticals Ltd.

Generic: Vonoprazan + Amoxicillin + Clarithromycin

4 Tablets (1 Strip)
৳ 54.54
৳ 60
9% OFF
Alternative Brands For Vonocab Trio

Medicine Overview of Vonocab Trio 20mg+500mg+500mg tablet

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Dosage

The recommended dosage regimen is- Vonoprazan 20 mg Amoxicillin 1000 mg Clarithromycin 500 mg Each given twice daily (morning and evening, 12 hours apart), with or without food, for 14 days. Geriatrics: The standard triple therapy regimen increased risk of torsade de pointes due to the clarithromycin component. Renal Impairment: Avoid use in severe renal impairment. Hepatic Impairment: Avoid use in moderate and severe hepatic impairment. Take medicine as per doctor's advice.

Interaction

Triple therapy regimen should be used with caution when co-administrated with following drugs: Tacrolimus, cyclosporine, clopidogrel, citalopram, cilostazol, probenecid, allopurinol, itraconazole, ketoconazole, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, saquinavir, ritonavir, etravirine, rilpivirine-containing products, atazanavir, nelfinavir.

Contraindications

The standard triple therapy regimen is contraindicated in patients with known hypersensitivity to vonoprazan, amoxicillin or any other betalactams, clarithromycin or any other macrolide antimicrobials

Side Effects

Side Effects

Precautions

Hypersensitivity Reactions: Serious and occasionally fatal reactions (e.g., anaphylaxis) have been reported with components of this triple pack. If hypersensitivity reactions occur, discontinue and institute immediate therapy (e.g., anaphylaxis management). Severe Cutaneous Adverse Reactions (SCAR): Discontinue this pack at the first signs or symptoms of SCAR or other signs of hypersensitivity and consider further evaluation. Clostridioides difficile-associated diarrhea (CDAD): Evaluate if diarrhea occurs with this pack and Due to the Clarithromycin Component: QT Prolongation: Avoid this pack in patients with known QT prolongation or receiving drugs known to prolong the QT interval, ventricular arrhythmia (torsades de pointes), hypokalemia/hypomagnesemia, significant bradycardia, or taking Class IA or III antiarrhythmics. Hepatotoxicity: Discontinue if signs and symptoms of hepatitis occur with this pack. Serious adverse reactions due to concomitant use with other drugs: Serious adverse reactions can occur with this pack due to drug interactions of clarithromycin with colchicine, some lipid lowering agents, some calcium channel blockers, and other drugs. Embryo-Fetal Toxicity: Based on the findings from animal studies and human observational studies in pregnant women treated with clarithromycin, this pack is not recommended for use in pregnant women except in clinical circumstances where no alternative therapy is appropriate. Myasthenia Gravis: Exacerbation of myasthenia gravis can occur with this pack since it has been reported in patients receiving clarithromycin tablets.

Overdose Effects

If overdose occurs, should consult with doctor immediately.

Storage Conditions

Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.

Brief Description

Indications

The standard triple therapy regimen is indicated in the eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers.

Pharmacology

Helicobacter pylori (H. pylori) is implicated in the etiology of gastritis & peptic ulcer. The standard triple therapy regimen contains 20 mg vonoprazan tablet, 500 mg amoxicillin capsule and 500 mg clarithromycin tablet for oral administration is effective for eradicating H. pylori. Vonoprazan suppresses basal and stimulated gastric acid secretion at the secretory surface of the gastric parietal cell through inhibition of the H+ K+ -ATPase enzyme system in a potassium competitive manner. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, vonoprazan has been characterized as a type of gastric proton-pump inhibitor, in that it blocks the final step of acid production. Vonoprazan does not require activation by acid. Vonoprazan may selectively concentrate in the parietal cells in both the resting and stimulated states. Vonoprazan binds to the active proton pumps in a noncovalent and reversible manner. Amoxicillin is an antibacterial drug. Clarithromycin is a macrolide antimicrobial drug. Acid suppression enhances the replication of H. pylori bacteria and the stability and effectiveness of antimicrobials in the treatment of H. pylori infection.

Buy Vonocab Trio from Arogga

In Bangladesh, you can get the original Vonocab Trio. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Vonocab Trio in Bangladesh?

The latest price of Vonocab Trio in Bangladesh is 54.54৳. You can buy Vonocab Trio at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
Consuming alcohol while taking Vonoprazan + Amoxicillin + Clarithromycin may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
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CONSULT YOUR DOCTOR
Based on findings from animal studies and observational studies in pregnant women with use of clarithromycin, use of this triple pack is not recommended in pregnant women except in clinical circumstances where no alternative therapy is appropriate.
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SAFE IF PRESCRIBED
There are no data regarding the presence of vonoprazan in human milk, the effects on the breastfed infant or the effects on milk production. Vonoprazan and its metabolites are present in animal study
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UNSAFE
Vonoprazan + Amoxicillin + Clarithromycin may cause side effects which could affect your ability to drive. Pylotrip can have side effects and the symptoms (such as allergic reactions, dizziness and convulsions) may make you unfit to drive.
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CAUTION
Vonoprazan + Amoxicillin + Clarithromycin should be used with caution in patients with kidney disease. Dose adjustment of Pylotrip may be needed. Please consult your doctor. Use of this medicine is not recommended in patients with severe kidney disease.
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CONSULT YOUR DOCTOR
Vonoprazan + Amoxicillin + Clarithromycin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Pylotrip may not be needed in these patients.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.