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Fibril
Beximco Pharmaceuticals Ltd.
Generic: Gemfibrozil
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Fibril. Please consult your doctor.
CONSULT YOUR DOCTOR
Fibril may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Fibril is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Fibril may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Fibril should be used with caution in patients with kidney disease. Dose adjustment of Fibril may be needed. Please consult your doctor.
Use of Fibril is not recommended in patients with severe kidney disease.
UNSAFE
Fibril is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Fibril 300mg Capsule
Introduction
Fibril is a medicine used to treat high cholesterol. This medicine helps by lowering triglycerides and "bad" cholesterol (LDL), while at the same time raising the levels of "good" cholesterol (HDL). Lowering cholesterol levels reduces the risk of heart attack and stroke. Fibril should be taken in the dose and duration as advised by the doctor. You can take it at any time of day without food but try to take it at the same time each day. Most people with high cholesterol do not feel ill, but if you stop taking this medicine, your condition could get worse. This...
... Show moreUses of Fibril
- High triglycerides
- High cholesterol
Side effects of Fibril
Common
- Increased liver enzymes
- Vomiting
- Nausea
- Abdominal pain
- Diarrhea
- Flatulence
How to use Fibril
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Fibril is to be taken empty stomach.
How Fibril works
Fibril is a lipid lowering medication. It works by lowering the levels of triglycerides and "bad" cholesterol (LDL), while raising the levels of "good" cholesterol (HDL).
What if you forget to take Fibril?
If you miss a dose of Fibril, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- It should be taken with food.
- Avoid alcohol consumption while taking this medication.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Notify your doctor if you are more tired than usual, do not feel hungry, or if you have yellow eyes, skin or dark urine.
- Inform your doctor if you experience muscle pain, tenderness, cramps, or weakness while taking Fibril, particularly if it is accompanied by a fever.
- Do not discontinue Fibril without consulting your doctor even if you feel better.
Brief Description
Indication
Hypertriglyceridemia, Hyperlipidemia
Administration
Should be taken on an empty stomach. Take ½ hr before meals.
Adult Dose
Hypertriglyceridemia, Hypercholesterolemia
600 mg PO q12hr
Hepatic impairment
Contraindicated
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
Mild to moderate: Use caution, if baseline serum creatine in patient is >2mg/dL; deterioration of renal function reported in such patients
Severe: Contraindicated
Contraindication
Hypersensitivity. Severe hepatic or renal dysfunction; gall stones; neonates, children, pregnancy, lactation.
Mode of Action
Gemfibrozil exhibits its action by inhibition of lipolysis and reduction of hepatic fatty acid uptake. It also inhibits secretion of VLDL from the liver.
Precaution
Causes of secondary hyperlipidaemia such as hypothyroidism and diabetes must be treated before initiating therapy. Renal impairment; blood disorders. Periodic monitoring of the serum lipids should be done; if no adequate response after 3 mth, treatment should be withdrawn. May increase risk of cholelithiasis.
Lactation: Not recommended
Side Effect
>10%
Dyspepsia (20%)
1-10%
Abdominal pain (10%),Atrial fibrillation (1%),Diarrhea (7%),Fatigue (4%),N/V (3%),Eczema (2%),Rash (2%),Vertigo (2%),Constipation (1%),Headache (1%)
<1%
Myalgia,Rhabdomyolysis (especially with admin with statin),Acute appendicitis,Cholelithiasis,Angioedema,Hypokalemia,Eosinophilia,Myopathy,Synovitis,Taste disturbance,Xerostomia,Flatulence,Rash
Potentially Fatal: Bone marrow hypoplasia; intracranial haemorrhage; nephrotoxicity; peripheral neuritis.
Interaction
Co-admin with repaglinide may increase serum levels of repaglinide. May enhance effects of oral anticoagulants. May also increase the plasma concentrations of ciclosporin and associated nephrotoxicity when used concurrently.
Potentially Fatal: Increased risk of myopathy and rhabdomyolysis when used with HMG-CoA reductase inhibitors.
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