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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Fragmin.
SAFE IF PRESCRIBED
Fragmin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Fragmin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Fragmin is released in small amounts in the breast milk and amounts reaching the baby are also small, which would not be expected to cause any harmful effects to the baby.
SAFE
Fragmin does not usually affect your ability to drive.
CAUTION
Fragmin should be used with caution in patients with severe kidney disease. Dose adjustment of Fragmin may be needed. Please consult your doctor.
CAUTION
Fragmin should be used with caution in patients with severe liver disease. Dose adjustment of Fragmin may be needed. Please consult your doctor.
Medicine Overview of Fragmin 7500IU/0.3ml Injection
Introduction
Fragmin is known as an anticoagulant and is used to prevent harmful blood clots. It stops existing clots getting any bigger and stops new ones forming in the legs, lungs, brain or heart. This can help prevent Acute coronary syndrome, Deep vein thrombosis and Pulmonary embolism. Fragmin is injected by or under the supervision of doctor. The dose and length of treatment are based on your medical condition, your response to the medicine and what you are being treated for. It may also be based on your age and weight. It is important to keep using this medicine even if...
... Show moreUses of Fragmin
- Acute coronary syndrome
- Deep vein thrombosis
- Pulmonary embolism
Side effects of Fragmin
Common
- Injection site reaction
How to use Fragmin
Your doctor or nurse will guide you how to use this medicine.
How Fragmin works
Fragmin is an anticoagulant that prevents the formation of harmful blood clots.
What if you forget to take Fragmin?
If you miss a dose of Fragmin, please consult your doctor.
Quick Tips
- Inform your doctor if you are also taking other medicines that increase the bleeding risk like aspirin and NSAIDs.
- Inform your doctor if there is bleeding from gums, nose or wounds that lasts more than 15 minutes or if blood appears in your urine, stool or vomit.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Unstable angina, Pulmonary embolism, Deep-vein thrombosis, Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration, Prophylaxis of venous thromboembolism during surgery
Adult Dose
Subcutaneous Venous thromboembolism Adult: 200 U/kg daily as a single or in 2 divided doses in pregnant and high-risk patients. Max: 18,000 U/day. Patients w/ symptomatic thromboembolism and cancer: 200 U/kg once daily for 30 days, followed by 150 U/kg once daily for up to 5 mth; if chemotherapy induced thrombocytopenia develops, reduce dose to 2,500 U while platelet counts are below 100,000 cells/mm3, temporarily stop treatment if platelet counts are below 50,000 cells/mm3. Prophylaxis of venous thromboembolism during surgical procedures Adult: Moderate risk patients: 2,500 U given 1-2 hr before the procedure followed by 2,500 U once daily for...
... Show moreChild Dose
Safety & efficacy not established
Renal Dose
Renal impairment: CrCl <30 mL/min: Dosage adjustment needed based on anti-Factor Xa activity.
Contraindication
Hypersensitivity. Active major bleeding, severe coagulation disorders; lumbar puncture; sympathetic block; brain, spinal cord, eye or ear surgery; severe hypertension.
Mode of Action
Dalteparin sodium is a low molecular weight heparin analogue which inhibits factor Xa more than factor IIa (thrombin).
Precaution
Preexisting thrombocytopenia, recent childbirth, DM, subacute bacterial endocarditis, pericarditis, recent lumbar puncture, vasculitis. Monitor coagulation time. Hepatic or renal dysfunction; high doses; osteoporosis; familial antithrombin III deficiency; elderly; children; platelet count and stool occult blood test recommended during treatment; GI ulceration. Pregnancy and lactation.
Lactation: Enters breast milk; use with caution
Side Effect
1-10%
Injection site hematoma (7-35%),Thrombocytopenia (10.9-13.6%, patients with cancer ),Injection site pain (4.5-12%),Major hemorrhage (up to 4.6%),Increased liver function test (up to 4.3%),Wound hematoma,Hematuria
Frequency Not Defined
Epidural hematoma,Spinal hematoma,Hemorrhagic cerebral infarction,Intracranial hemorrhage,Intrauterine subdural hemorrhage,Thrombocytopenia (<1%, non-cancer indications),Anaphylactoid reaction (rare)
Potentially Fatal: Severe haemorrhage.
Pregnancy Category Note
Pregnancy Available data have not reported a clear association with dalteparin and adverse developmental outcomes There are risks to the mother associated with untreated VTE in pregnancy, and a potential for adverse effects on the preterm infant when used in pregnancy Clinical considerations Published data describe that women with a previous history of VTE in pregnancy are at higher risk for recurrence during subsequent pregnancies compared to those with no risk factor for VTE Cases of “gasping syndrome” have occurred in premature infants when large amounts of benzyl alcohol have been administered (99-404 mg/kg/day) Multiple-dose 3.8 mL vials of dalteparin...
... Show moreInteraction
Increased risk of haemorrhage w/ other anticoagulant/antiplatelet agents (e.g. aspirin/dipyridamole, glycoprotein IIb/IIIa receptor antagonists, vit K antagonists, NSAIDs, cytostatics, dextran, thrombolytics, sulfinpyrazone, probenecid, etacrynic acid). Reduced anticoagulant effect w/ antihistamines, cardiac glycosides, tetracycline and ascorbic acid.
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৳50
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৳40
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৳30
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৳20
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৳10
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.