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Edruc Ltd.
Generic: Amitriptyline Hydrochloride
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descriptionSafety Advices
It is unsafe to consume alcohol with Amtylin.
Amtylin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing... View More
Amtylin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Amtylin may cause side effects which could affect your ability to drive. Amtylin may impair your alertness which may affect your ability to drive.
Amtylin is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Amtylin may not be needed in th... View More
Amtylin should be used with caution in patients with liver disease. Dose adjustment of Amtylin may be needed. Please consult your doctor. Use of Amtylin... View More
descriptionMedical Overview


Amtylin is used in the treatment of depression. It is also used to treat and prevent chronic nerve-related (neuropathic) pain, migraine, tension-type he... View More

Uses of Amtylin

  • Depression
  • Neuropathic pain
  • Migraine

Side effects of Amtylin

  • Constipation
  • Difficulty in urination
  • Dryness in mouth
  • Increased heart rate
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Weight gain
  • Aggressive behavior
  • Agitation
  • Nasal congestion (stuffy nose)

How to use Amtylin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amtylin may be taken with ... View More

How Amtylin works

Amtylin is a tricyclic antidepressant. It works by increasing the levels of chemical messengers in the brain that help in regulating mood and treat depr... View More

What if you forget to take Amtylin?

If you miss a dose of Amtylin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your r... View More

quick tipsQuick Tips
  • It may take 4 to 6 weeks for Amtylin to start working. Keep taking it as prescribed.
  • It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking Amtylin as it may cause excessive sleepiness.
  • Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
  • It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
descriptionBrief Description


Adult: PO Depression Initial:50-75 mg/day; up to 150 mg/day if needed. Max: 300 mg/day in severe cases. Neuropathic pain Initial: 10-25 mg/day at nigh... View More


Increased risk of serotonin syndrome w/ SSRIs, TCAs, triptans, fentanyl, lithium, tramadol. May reduce plasma levels w/ barbiturates, rifampicin and oth... View More

Adult Dose

Bipolar illness, pregnancy, lactation elderly, CVS disease, renal or liver impairment, epilepsy, thyroid dysfunction, DM. Avoid abrupt withdrawal; urina... View More

Renal Dose

Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by... View More


PO Depression Child: Adolescent: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses. Nocturnal enuresis Child: 6-10 yr 10-2... View More

Mode of Action

May be taken with or without food.


Migraine headache, Depression, Neuropathic pain, Post-herpetic neuralgia, Nocturnal enuresis

Pregnancy Category Note

Postural hypotension, tachycardia, conduction disturbances. Dry mouth, wt gain, sour or metallic taste, stomatitis, constipation; blurring of vision, ur... View More


Hypersensitivity, use of MAO inhibitors within the last 14 days; acute recovery phase post-MI. Concurrent usage with cisapride.

Alternative brand for Amtylin
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More