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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Lorazem.
CONSULT YOUR DOCTOR
Lorazem is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Lorazem is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lorazem should be used for short periods and sleepiness of the baby should be watched. The withdrawal of Lorazem should be gradual.
UNSAFE
Lorazem may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Lorazem should be used with caution in patients with severe kidney disease. Dose adjustment of Lorazem may be needed. Please consult your doctor.
However, inform your doctor if you have any underlying kidney disease.
CAUTION
Lorazem should be used with caution in patients with severe liver disease. Dose adjustment of Lorazem may be needed. Please consult your doctor.
Use of Lorazem is not recommended in patients with severe liver disease.
Medicine Overview of Lorazem 1mg/2.5mg Tablet
Introduction
Lorazem is a prescription medicine used to treat anxiety disorders such as generalized anxiety disorder (excessive worry or restlessness), obsessive compulsive disorder (OCD), panic attacks and social phobias. It is also used for the short-term relief of the symptoms of anxiety. Lorazem relieves symptoms of anxiety such as nervousness, rapid breathing, increased heart rate, excessive sweating, trembling, weakness or lack of concentration. It may be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration...
... Show moreUses of Lorazem
- Short term anxiety
- Anxiety disorder
Side effects of Lorazem
Common
- Dizziness
- Weakness
- Sedation
- Balance disorder (loss of balance)
How to use Lorazem
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lorazem may be taken with or without food, but it is better to take it at a fixed time.
How Lorazem works
Lorazem is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Lorazem?
If you miss a dose of Lorazem, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
- It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
- Avoid consuming alcohol as it may increase dizziness and drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.
Brief Description
Indication
Anxiety, Status epilepticus, Sedation, psychosomatic, organic or psychotic illness, insomnia associated with anxiety, nervousness, restlessness, nausea and vomiting, related to chemotherapy and anticonvulsants, and as a premedicant before dental or general surgery or prior to investigative procedures where there may be discomfort.
Administration
May be taken with or without food.
Reconstitution: Dilute w/ an equal volume of compatible diluent (e.g. sterile water for inj, NaCl 0.9% inj, dextrose 5% inj).
Oral concentrate soln: Dose should be added to 30 mL or more of diluent (e.g. water, juice, carbonated or soda-like beverage) or to semi-solid food (e.g. applesauce, pudding).
Adult Dose
Oral Anxiety Disorders Adult: 1-6 mg/day in 2 or 3 divided doses, up to 10 mg/day. Insomnia associated w/ anxiety 1-4 mg/day at bedtime. Premed in surgery 2-3 mg the night before operation, then a smaller dose in the morning if needed. Parenteral Preoperative Sedation, Anxiety Relief, & Anterograde Amnesia 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg/dose in elderly), OR 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg/dose in elderly) Status Epilepticus Usual 4 mg/dose slow IV at 2 mg/min If...
... Show moreChild Dose
Status Epilepticus
Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat q10-15min PRN
Alternatively, 0.1 mg/kg at slow IV rate not to exceed rate of 2 mg/min; not to exceed dose of 4 mg
Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again
Renal Dose
Renal impairment
PO: Dose adjustment not necessary
IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure
Contraindication
Severe hepatic impairment; respiratory depression; acute narrow-angle glaucoma; pregnancy and lactation.
Mode of Action
Lorazepam is a short acting benzodiazepine. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS (including the limbic system, reticular formation) and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
Precaution
Patient w/ compromised pulmonary function (decreased reserve), myasthenia gravis, CV or cerebrovascular disease, impaired gag reflex; at risk of falls. Patient w/ history of alcohol or drug abuse and those w/ personality disorders. Not intended for treatment of primary depressive or psychotic disorders. It should not be administered by intra-arterial inj. Avoid abrupt withdrawal. Renal and mild to moderate hepatic impairment. Elderly or debilitated patients, childn. Pregnancy and lactation. Patient Counselling May impair ability to perform activities requiring mental alertness or physical coordination (e.g. driving, operating machinery) for 24-48 hr following admin of the drug. Monitoring Parameters Monitor resp and...
... Show moreSide Effect
Sedation, drowsiness, ataxia, dizziness, confusion, depression, unmasking of depression, hypotension, fatigue, muscle weakness, asthenia, transient anterograde amnesia or memory impairment, changes in vital signs (e.g. resp rate, BP). Thrombocytopenia, agranulocytosis, pancytopenia, hyponatraemia, disinhibition, euphoria, suicidal ideation, nausea, constipation, change in libido, impotence, decreased orgasm. Increase in bilirubin, liver transaminases or alkaline phosphatase.
Potentially Fatal: Resp depression.
Interaction
Drugs that affect the CNS (e.g. barbiturates, phenothiazines, antidepressants, MAOIs) may have additive CNS effects. Scopolamine may increase sedation, hallucinations and irrational behaviour. May reduce sedative and anxiolytic effect w/ caffeine, theophylline or aminophylline. May increase plasma level w/ Na valproate or probenecid.
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