Introduction
Antial 12 is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness which gradually affects memory and thinking. It does not cure this illnesses but may help improve memory, awareness and other symptoms.
Your doctor will explain how to take Antial 12 and give you the one most suitable for you. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. You may take it with food, preferably at night before going to bed. It can take up to few weeks for symptoms to improve so keep taking your medicine regularly. You should not stop taking this medicine without consulting your doctor.
Some common side effects of this medicine include diarrhea, nausea, vomiting, loss of appetite and weight loss. Some people may experience dizziness, increase in blood pressure or decreased heart rate. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to the Antial 12. If they are severe or will not go away, you should contact your doctor.
Before using Antial 12, you should tell your doctor if you have ever had heart problems, stomach ulcer, epilepsy or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. During pregnancy this medicine should only be taken if it is advised.
Side effects of Antial 12
How to use Antial 12
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Antial 12 is to be taken with food.
How Antial 12 works
Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Antial 12 is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.
What if you forget to take Antial 12?
If you miss a dose of Antial 12, skip it and continue with your normal schedule. Do not double the dose.
Indication
Dementia in Alzheimer's disease.
Administration
Should be taken with food.
Adult Dose
Alzheimer Disease
Initial
4 mg PO q12hr
Maintenance
Titrate to 8-12 mg PO q12hr; increase by 4 mg q12hr at no less than 4 week intervals
Hepatic Impairment
Moderate: (Child-Pugh score 7-9): Not to exceed 16 mg/day
Severe: Not recommended
Child Dose
Not recommended
Renal Dose
Renal Impairment
Moderate: Not to exceed 16 mg/day
Severe (CrCl <9 mL/min): Not recommended
Contraindication
Hypersensitivity; severe liver or kidney dysfunction; lactation; disorders of galactose metabolism; urinary retention or GI obstruction. Lactation.
Mode of Action
Galantamine is a centrally-acting cholinesterase inhibitor, elevating acetylcholine in the cerebral cortex. Glutamine and serotonin levels may also be increase. It has nicotinic receptor agonist properties.
Precaution
Mild-moderate hepatic impairment; supraventricular conduction abnormalities; asthma; COPD; pregnancy; peptic ulcers. May increase gastric acid production.
Side Effect
>10%
Nausea (20-25%),Diarrhea (11-15%),Vomiting (11-15%)
1-10%
Abdominal pain,Anorexia,Muscle cramp,Fatigue,Dizziness,Headache,Weight loss,Depression,Insomnia,UTI,Somnolence,Anemia,Syncope,Bradycardia
Potentially Fatal: CV effects; convulsion; delirium; rectal haemorrhage; thrombocytopenia.
Interaction
ncreased serum concentrations when used with drugs that inhibit CYP2D6 (e.g. quinidine, fluoxetine, fluvoxamine, and paroxetine) and CYP3A4 (e.g. ketoconazole and ritonavir). Cimetidine may increase the bioavailability of galantamine. Increased risk of gastric ulcer when used with NSAIDs.
Potentially Fatal: Amiodarone, ?-blockers, diltiazem or verapamil; NSAIDs; digoxin.