Protopa20mg

Indication

Peptic ulcer disease, H. pylori infection, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Oesophagitis, Acid-related dyspepsia, NSAID-as... View More

Administration

Controlled-release: Should be taken on an empty stomach. Take 1 hr before meals. Swallow whole, do not chew/crush. Normal release: May be taken with or... View More

Adult Dose

Erosive Esophagitis Associated With GERD Treatment: 40 mg PO qDay for 8-16 weeks Maintenance of healing: 40 mg PO qDay Alternatively, 40 mg IV qDay f... View More

Child Dose

Erosive Esophagitis Associated With GERD <5 years: Safety and efficacy not established >5 years 15 kg to <40 kg: 20 mg PO qDay for up to 8 weeks 40 ... View More

Renal Dose

Renal impairment: No dosage adjustment needed.

Contraindication

Concomitant use w/ rilpivirine, atazanavir and nelfinavir. Lactation.

Mode of Action

Pantoprazole is a substituted benzimidazole, and also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATP... View More

Precaution

Gastric malignancy should be ruled out. Consider Zn++ supplementation during IV therapy in patients who are prone to Zn++ deficiency. Pregnancy. Monitor... View More

Side Effect

1-10% Headache (>4%),Abdominal pain (4%),Facial edema (<4%),Generalized edema (<2%),Chest pain (4%),Diarrhea (4%),Constipation (<4%),Pruritus (4%),Rash... View More

Pregnancy Category Note

Risk Summary Available data from published observational studies did not demonstrate an association of major malformations or other adverse pregnancy o... View More

Interaction

Increased risk of digoxin-induced cardiotoxic effects. Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time of warfarin... View More