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General Pharmaceuticals Ltd.
Generic: Leflunomide
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descriptionSafety Advices
It is unsafe to consume alcohol with Arolef.
Arolef is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effec... View More
Arolef is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Arolef may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Arolef should be used with caution in patients with kidney disease. Dose adjustment of Arolef may be needed. Please consult your doctor.
Arolef is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
descriptionMedical Overview


Arolef is used in the treatment of rheumatoid arthritis and psoriatic arthritis. It helps in slowing down the progression of the disease and provide rel... View More

Uses of Arolef

  • Rheumatoid arthritis
  • Psoriatic arthritis

Side effects of Arolef

  • Nausea
  • Headache
  • Rash
  • Diarrhea
  • Increased liver enzymes
  • Respiratory tract infection

How to use Arolef

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arolef may be taken with o... View More

How Arolef works

Arolef blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain autoimmune d... View More

What if you forget to take Arolef?

If you miss a dose of Arolef, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your re... View More

quick tipsQuick Tips
  • You have been prescribed Arolef to control the symptoms and slow down the progression of rheumatoid arthritis.
  • It will take 6-8 weeks for Arolef to work. Hence, keep taking the medicine.
  • Get blood tests done every 4 weeks. This is to make sure that Arolef is not harming your liver or blood counts.
  • Avoid alcohol when taking Arolef as it could harm your liver.
  • Do not take it during pregnancy or breastfeeding. Tell your doctor if you become pregnant while taking Arolef.
  • Arolef may increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
  • Tell your doctor if you experience nausea or diarrhea.
descriptionBrief Description


Rheumatoid arthritis, Psoriatic arthritis


May be taken with or without food.

Adult Dose

Oral Rheumatoid arthritis; Psoriatic arthritis Adult: Loading dose: 100 mg once daily for 3 days. Maintenance: 10-20 mg once daily. Hepatic impairm... View More

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: Mild: No dosage adjustment needed. Moderate to Severe: Contraindicated.


Significant hepatic impairment, compromised immune function including bone marrow dysplasia or severe uncontrolled infection; concurrent vaccination wit... View More

Mode of Action

Leflunomide is an immunomodulating agent and DMARD. It inhibits pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase enzyme activity resultin... View More


Renal and hepatic impairment; Women with childbearing potential. Caution should be taken for those female with child bearing potential who are not using... View More

Side Effect

>10% Diarrhea (17%),Respiratory infections (15%) 1-10% (selected) Alopecia (10%),Hypertension (10%),Rash (10%),Nausea (9%),Bronchitis (7%),Headache... View More


Cholestyramine and activated charcoal may decrease plasma concentration of active metabolite. Concurrent use of methotrexate and other hepatotoxic drugs... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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