Arthrofen50mg+200mcg

Indication

Rheumatoid arthritis, Osteoarthritis, Joint and muscular pains

Administration

Swallow tablet whole, do not chew or crush Do not take with antacids

Adult Dose

Osteoarthritis 50 mg/200 mcg, 75mg/200mcg: 1 tab PO three times daily; not to exceed 200 mcg misoprostol/dose or 800 mcg/day Rheumatoid Arthritis 5... View More

Child Dose

Safety & efficacy not established

Contraindication

Diclofenac Sodium and Misoprostol combination is contraindicated in women who are pregnant because of the abortive property of the Misoprostol component... View More

Mode of Action

Diclofenac: Inhibits cyclooxygenase-1 (COX-1) & -2 (COX-2), thereby inhibiting prostaglandin synthesis; has anti-inflammatory, antipyresis, and analgesi... View More

Precaution

Patients with an underlying condition such as inflammatory bowel disease or those in whom dehydration should be monitored carefully if Diclofenac Sodium... View More

Side Effect

>10% Rash including erythematous, rash macular and maculo-papular (18%),Pyrexia (15%),Urticaria (13%),Flushing (13%) 1-10% Hypertension (10%),Hyper... View More

Pregnancy Category Note

Pregnancy Category: X Lactation: Enters breast milk; use with caution

Interaction

May increase serum levels of methotrexate. Concomitant use w/ other NSAIDs or anticoagulants (e.g. warfarin) is associated w/ higher risk of GI bleedin... View More