Introduction
Asmacon SR is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe.
Asmacon SR can be taken with the food in evening. But take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Do not miss even a single dose, if in any case, you missed a dose, take it as soon as you remember or better to skip the missed dose and continue with regular dosing. It does not work immediately or prevent the already started breathing trouble , hence always carry your medical inhaler with you for an emergency.
The most common side effects of this medicine include vomiting, headache, nausea, and stomach upset. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Generally, it is advised not to consume alcohol or do not smoke while on treatment. You must avoid high caffeinated products like coffee, tea, and dark chocolates as it enhances drug side effects.
Before taking this medicine, let your doctor if you have kidney or liver disease or if you have heart-related problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant or breastfeeding before starting the treatment.
Uses of Asmacon SR
- Chronic obstructive pulmonary disease (COPD)
- Asthma
Side effects of Asmacon SR
Common
- Upset stomach
- Vomiting
- Headache
- Nausea
- Restlessness
How to use Asmacon SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Asmacon SR is to be taken with food.
How Asmacon SR works
Asmacon SR is a bronchodilator. It works by relaxing the muscles of the airways and widens airways. This makes breathing easier.
Indication
Asthma, Chronic obstructive pulmonary disease, Bronchospasm, Apnoea of prematurity
Administration
May be taken with or without food, at least 1 hour before or 2 hour after meal.
Adult Dose
Oral
Acute Asthma
Loading Dose: 5 mg/kg loading dose (patient not receiving theophylline or aminophylline).
Maintenance of Asthma, COPD
General Dosing Recommendations
The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects.
Maintenance Dose: 10-16/mg/kg/day
Adult: Starting Dose: 300-400mg/day once or twice daily.
After 3 days if tolerated, increase dose to 400-600mg/day once or twice dialy.
Max: 600mg/day
Adult: As SR/CR Cap or Tab, 200/300 mg:
One tablet/capsule every 12 hourly.
As 400mg tablet/capsule
One tab/cap is once daily in the evening.
Elderly: Lower doses should be used.
Hepatic impairment: Reduce dose.
Child Dose
Oral
Acute Asthma
Loading Dose: 5 mg/kg loading dose If no theophylline has been administered in the previous 24 hours
2.5 mg/kg loading dose If theophylline has been administered in the previous 24 hours
Maintenance of Asthma
General Dosing Recommendations
The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects.
Maintenance Dose:
Child
1.5-6 months: 10 mg/kg/day PO in divided doses
6-12 months: 12-18 mg/kg/day PO in divided doses
1-9 years: 8 mg/kg PO (extended release) q8hr
9-12 years: 6.4 mg/kg PO (extended release) q8hr
12-16 years: 5.6 mg/kg PO (extended release) q8hr
Child 1-15 years <45 kg:
Starting Dose: 12-14 mg/kg/day up to a maximum of 300 mg/day
After 3 days if tolerated, increase dose to 16 mg/kg/day up to a maximum of 400 mg/day administration.
After more days, if tolerated, and if needed increase dose to 20 mg/kg/day up to a maximum of 600 mg/day
Child 1-15 years >45 kg:
Starting Dose: 300-400mg/day once or twice daily.
After 3 days if tolerated, increase dose to 400-600mg/day once or twice dialy.
Max: 600mg/day
Contraindication
Hypersensitivity to xanthine derivatives, porphyria.
Mode of Action
Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion.
Precaution
Patient w/ peptic ulceration, hyperthyroidism, DM, glaucoma, severe hypoxemia, epilepsy, HTN, heart failure, cardiac arrhythmias or other CV disease, acute febrile illness, COPD, cor pulmonale; smokers. Hepatic or renal impairment. Elderly and childn. Pregnancy and lactation. Monitoring Parameters Monitor heart rate, CNS effects, resp rate, arterial or capillary blood gases, theophylline levels.
Lactation: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants; serious adverse effects in infant are unlikely unless mother has toxic serum theophylline concentration
Side Effect
Nausea, vomiting, epigastric pain, abdominal cramps, anorexia, diarrhoea, haematemesis; headache, irritability, restlessness, nervousness, insomnia, dizziness, reflex hyperexcitability, seizures; palpitations, sinus tachycardia, extrasystoles, increased pulse rate, flushing, circulatory failure, hypotension, ventricular arrhythmias; transient increase in urinary frequency, dehydration, twitching of fingers and hands, tachypnoea, elevated serum AST concentrations.
Potentially Fatal: Convulsions, cardiac arrhythmias, severe hypotension or cardiac arrest.
Interaction
Increased plasma concentrations w/ allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibiotics, quinolones, OCs, tiabendazole, viloxazine, Ca channel blockers. Reduced plasma concentrations w/ phenytoin and other antiepileptics, ritonavir, rifampicin, sulfinpyrazone, aminoglutethimide, barbiturates, carbamazepine. Enhanced lithium excretion. May potentiate hypokalaemia w/ corticosteroids and diuretics. Risk of synergistic toxicity when given w/ halothane or ketamine. May antagonise effects of adenosine and competitive neuromuscular blockers. Increased bronchospasm w/ β-blockers.