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Risedon Plus
Square Pharmaceuticals PLC.
Generic: Risedronate Sodium + Calcium
Medicine Overview of Risedon Plus 35mg Tablet
বাংলা
English
Indication
Treatment and prevention of, osteoporosis in postmenopausal women. It can be also used to increase bone mass in men with osteoporosis, Paget’s disease of bone.
Adult Dose
Adult: PO: 1 tablet should be taken orally once a week (Day 1 of the 7-day treatment cycle) then 01 Calcium 500 mg tablet should be taken orally with food daily on each of the remaining 6 days (Days 2 through 7 of the 7-day treatment cycle).
Contraindication
Risedronate Sodium is not recommended for use in patients with severe renal impairment (creatinine clearance <30 ml/min). Pregnancy & Lactation.
Mode of Action
Risedronic acid inhibits bone resorption by inhibiting osteoclasts. It also prevents formation and dissolution of hydroxyapatite crystals, and therefore may interfere with bone mineralisation.
Calcium is used to prevent or treat negative calcium balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways.
Precaution
Take special care if:
• have low blood calcium (hypocalcemia).
• cannot sit or stand up for 30 minutes.
• have kidneys that work poorly.
• have an allergy to Risedronate Sodium.
• are pregnant or may become pregnant.
• are breast-feeding or plan to breast-feed.
• have kidney problems.
Side Effect
Chest pain, difficulty or pain when swallowing, pain or burning under the ribs or in the back, new or worsening heartburn, severe joint, bone, or muscle pain, jaw pain, numbness, or swelling, mild heartburn or stomach upset, diarrhea, gas, or constipation, mild joint or back pain, headache.
Interaction
Risedronate Sodium: Co-admin with calcium, antacids or oral medications containing divalent cations may affect the absorption of risedronate. May have additive calcium lowering effects when used with aminoglycosides.
Calcium: Co-administration with thiazide diuretics or vit D may lead to milk-alkali syndrome and hypercalcaemia. Decreased absorption with corticosteroids. Decreases absorption of tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn and calcium-channel blockers. Enhances cardiac effects of digitalis glycosides and may precipitate digitalis intoxication.
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