Square Pharmaceuticals Ltd.
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Caution is advised when consuming alcohol with Barif 40. Please consult your doctor.
CONSULT YOUR DOCTOR
Barif 40 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developin... View More
CONSULT YOUR DOCTOR
Barif 40 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Barif 40 may cause side effects which could affect your ability to drive. Barif 40 may cause dizziness, sleepiness, blurred vision, numbness or tingling... View More
Barif 40 should be used with caution in patients with severe kidney disease. Dose adjustment of Barif 40 may be needed. Please consult your doctor. Limi... View More
Barif 40 should be used with caution in patients with severe liver disease. Dose adjustment of Barif 40 may be needed. Please consult your doctor. Limit... View More
Barif 40 is a medicine used to treat and prevent gout. Gout happens when there is too much uric acid in your body and it forms into crystals which can a... View More
Uses of Barif 40
Side effects of Barif 40
- Increased liver enzymes
- Skin rash
- Gout flares
How to use Barif 40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Barif 40 may be taken with... View More
How Barif 40 works
Barif 40 is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.
What if you forget to take Barif 40?
If you miss a dose of Barif 40, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your ... View More
- Your doctor has prescribed Barif 40 to reduce episodes of gout attack.
- Take it at the same time every day, with or without food.
- Take plenty of fluids (2-3 litres) daily while on Barif 40.
- When you first start taking this medicine, you might have more gout attacks. Do not stop Barif 40 on having an acute attack of gout as that could make a... View More
- Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
- Stop taking this medicine and inform your doctor straight away if you have symptoms like rash, itchiness, difficulties in breathing, fever or swelling o... View More
May be taken with or without food. May be taken w/o regard to antacid use.
Chronic Gout 40 mg/day PO initially; maintenance: 40-80 mg/day; increased if serum uric acid is >6 mg/mL after 2 weeks Hepatic impairment Mild to m... View More
Safety and efficacy not established
Renal impairment Mild to moderate (CrCl 30-89 mL/min): Dosage adjustment not necessary Severe (CrCl <30 mL/min): Data not available; use with caution
Patients being treated with azathioprine, mercaptopurine, or theophylline.
Mode of Action
Febuxostat selectively inhibits xanthine oxidase, the enzyme that catalyses the conversion of hypoxanthine to xanthine to uric acid, thereby decreasing ... View More
Cardiovascular death Patients with established cardiovascular (CV) disease treated with febuxostat had a higher rate of CV death compared with those tr... View More
>1% Arthralgia,Elevated liver function test (LFT) results,Liver function abnormalities,Nausea,Rash
Pregnancy Category Note
Pregnancy Limited available data in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes Animal data ... View More
May increase plasma conc of mercaptopurine, azathioprine. Alteration of metabolism of xanthine oxidase substrate drugs (eg theophylline).
Alternative brand for Barif 40
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More