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Uronase
Beacon Pharmaceuticals PLC
Generic: Urokinase
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Uronase. Please consult your doctor.
SAFE IF PRESCRIBED
Uronase is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Uronase is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
NOT RELEVANT
Not relevant, as Uronase is intended for use in hospitalised patients.
SAFE IF PRESCRIBED
Uronase is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Uronase may not be needed in these patients. Please consult your doctor.
Use of Uronase is not recommended in patients with severe kidney disease.
CAUTION
Uronase should be used with caution in patients with liver disease. Dose adjustment of Uronase may be needed. Please consult your doctor.
Medicine Overview of Uronase 500000IU/10ml Injection
Introduction
Uronase is a medicine used to break down harmful blood clots that have formed in the blood vessels. It is used to treat patients who have suffered a recent heart attack. It is also used in treating conditions such as pulmonary embolism and stroke. Uronase is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. The doctor may closely monitor your condition till you became stable. Use of this medicine may cause nausea, injection site bleeding, allergic reaction, and decrease in blood pressure. It may increase your risk of...
... Show moreUses of Uronase
- Heart attack
- Pulmonary embolism
Side effects of Uronase
Common
- Allergic reaction
- Nausea
- Vomiting
- Injection site bleeding
How to use Uronase
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Uronase works
Uronase works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.
What if you forget to take Uronase?
If you miss a dose of Uronase, please consult your doctor.
Quick Tips
- It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, using sharp objects or engaging in contact sports (e.g. football, wrestling).
- Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.
Brief Description
Indication
Acute MI, Pulmonary embolism, Thromboembolism, Deep vein thrombosis
Adult Dose
Intravenous Deep vein thrombosis Adult: Initially, 4400 units/kg dissolved in 15 ml of sodium chloride 0.9%, infused IV over 10 minutes followed by 4400 units/kg/hr for 12-24 hr. Parenteral Acute myocardial infarction Adult: 6000 units/min infused into the coronary artery for 2 hr preceded by IV heparin. Alternatively, 2-3 million units IV is given over 45-90 min. Intravenous Peripheral arterial thromboembolism Adult: As solution containing 2000 units/ml: Infuse into the clot via a catheter at a rate of 4000 units/minute for 2 hr. Monitor response using angiography. If clot is not removed, advance the catheter into the occluded vessel and...
... Show moreContraindication
Active internal bleeding; history of cerebrovascular accident; recent (within 2 mth) trauma of any kind including surgery; aneurysm; known bleeding diathesis; severe uncontrolled hypertension. Recent history of peptic ulcer disease, oesophageal varices, ulcerative colitis or other bleeding GI lesions; pancreatitis; subacute bacterial endocarditis; coagulation defects including those due to liver or kidney disease, or after recent surgery, childbirth or trauma. Increased risk of cerebral bleeding e.g. recent stroke or cerebral neoplasm. Pregnancy.
Mode of Action
Urokinase, an enzyme isolated from human urine, directly converts plasminogen into plasmin, which is a proteolytic enzyme with fibrinolytic effects. It is a fibrin non-specific thrombolytic as it affects both unbound and fibrin bound plasminogen.
Precaution
Any vascular punctures or invasive procedures should be avoided as far as possible during, and immediately before and after urokinase therapy and if unavoidable done with great care. External chest compression. Caution in conditions eg, possibility of left heart thrombus, subacute bacterial endocarditis, coagulation defects, cerebrovascular disease, diabetic retinopathy and any conditions in which bleeding could be dangerous. Monitor for reperfusion arrhythmias when used in MI.
Side Effect
Bleeding, pyrexia, haematuria, thromboembolic episodes, hypersensitivity reactions.
Potentially Fatal: Severe bleeding, anaphylaxis.
Interaction
Reduced thrombolytic effect when given again some time later due to development of high levels of antibodies.
Potentially Fatal: Platelet inhibitors eg, aspirin and indometacin can potentiate the action of urokinase and cause haemorrhage. Heparin and oral anticoagulants may increase risk of bleeding.
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