Biofol 1515mg
Tablet
Incepta Pharmaceuticals Ltd.
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Indication
Colorectal cancer, Methotrexate toxicity, Megaloblastic anaemia
Adult Dose
Oral Antidote for methotrexate toxicity Adult: 15 mg every 6 hr for 10 doses starting 24 hr after the start of methotrexate infusion. Continue admin u... View More
Contraindication
Hypersensitivity, pernicious anaemia and other megaloblastic anaemias secondary to vit B12-deficiency, intrathecal and intraventricular admin.
Mode of Action
Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP an... View More
Precaution
Undiagnosed megaloblastic anaemia, folate dependent tumors; pregnancy. Monitor calcium levels in patients receiving combined 5-Fluorouracil/Folinic acid... View More
Side Effect
Allergic sensitisation, rash, pruritus, eythema, urticaria, nausea, vomiting, pyrexia.
Interaction
Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together. Some adverse effects that have o... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More