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Biofol 1515mg

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Incepta Pharmaceuticals Ltd.
Generic: Folinic Acid (Calcium folinate)
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descriptionMedical Overview


Colorectal cancer, Methotrexate toxicity, Megaloblastic anaemia

Adult Dose

Oral Antidote for methotrexate toxicity Adult: 15 mg every 6 hr for 10 doses starting 24 hr after the start of methotrexate infusion. Continue admin u... View More


Hypersensitivity, pernicious anaemia and other megaloblastic anaemias secondary to vit B12-deficiency, intrathecal and intraventricular admin.

Mode of Action

Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP an... View More


Undiagnosed megaloblastic anaemia, folate dependent tumors; pregnancy. Monitor calcium levels in patients receiving combined 5-Fluorouracil/Folinic acid... View More

Side Effect

Allergic sensitisation, rash, pruritus, eythema, urticaria, nausea, vomiting, pyrexia.


Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together. Some adverse effects that have o... View More


The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More

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