Biofol 55mg
Tablet
Incepta Pharmaceuticals Ltd.
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Indication
Colorectal cancer, Methotrexate toxicity, Megaloblastic anaemia
Adult Dose
Oral Antidote for methotrexate toxicity Adult: 15 mg every 6 hr for 10 doses starting 24 hr after the start of methotrexate infusion. Continue admin u... View More
Contraindication
Hypersensitivity, pernicious anaemia and other megaloblastic anaemias secondary to vit B12-deficiency, intrathecal and intraventricular admin.
Mode of Action
Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP an... View More
Precaution
Undiagnosed megaloblastic anaemia, folate dependent tumors; pregnancy. Monitor calcium levels in patients receiving combined 5-Fluorouracil/Folinic acid... View More
Side Effect
Allergic sensitisation, rash, pruritus, eythema, urticaria, nausea, vomiting, pyrexia.
Interaction
Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together. Some adverse effects that have o... View More
Alternative brand for Biofol 5
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More