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Depomed 500 Injection
Drug International Ltd.
Generic: Methylprednisolone
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Depomed 500 Injection.
CONSULT YOUR DOCTOR
Depomed 500 Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Depomed 500 Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Depomed 500 Injection may cause side effects which could affect your ability to drive.
Undesirable effects, such as dizziness, vertigo, visual disturbances and fatigue are possible after treatment with Depomed 500 Injection. This may affect your driving ability.
SAFE IF PRESCRIBED
Depomed 500 Injection is safe to use in patients with kidney disease. No dose adjustment of Depomed 500 Injection is recommended.
However, talk to your doctor if you have any underlying kidney disease.
CONSULT YOUR DOCTOR
There is limited information available on the use of Depomed 500 Injection in patients with liver disease. Please consult your doctor.
Medicine Overview of Depomed 500 Injection 500mg/vial Injection
Introduction
Depomed 500 Injection is a medicine used to treat wide variety of medical conditions such as severe conditions, asthma, rheumatic disorder, skin and eye disorders, and nephrotic syndrome. It provides relieve by preventing the release of substances that cause inflammation. Depomed 500 Injection should be taken with food. This will prevent you from getting an upset stomach. The dose and duration will depend on what you are being treated for. You should always take the amount prescribed. Do not take a larger dose or use it more often. Keep taking it regularly even if you feel well. Some conditions will...
... Show moreUses of Depomed 500 Injection
- Rheumatic disorder
- Skin disorders
- Eye disorders
- Nephrotic syndrome
- Systemic lupus erythematosus (SLE)
Side effects of Depomed 500 Injection
Common
- Thinning of skin
- Increased risk of infection
- Reduction in bone density
- Weight gain
- Mood changes
- Upset stomach
- Behavioural changes
How to use Depomed 500 Injection
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depomed 500 Injection is to be taken with food.
Avoid Depomed 500 Injection with dietary sodium.
How Depomed 500 Injection works
Depomed 500 Injection is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
Quick Tips
- Depomed 500 Injection helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
- Do not use it more often or for longer than advised by your doctor.
- Take it with food to avoid an upset stomach.
- Depomed 500 Injection can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
- Side effects such as mood changes or stomach problems can happen when you start taking Depomed 500 Injection. Inform your doctor if this bothers you.
- Do not stop taking Depomed 500 Injection suddenly without talking to your doctor first as it may worsen your symptoms.
Brief Description
Indication
Anti-inflammatory or immunosuppressive, Allergic conditions
Administration
Should be taken with food.
Adult Dose
Oral Anti-inflammatory or immunosuppressive Adult: Initially, 2-60 mg daily in 1-4 divided doses, depending on the disease being treated. Allergic conditions Adult: 24 mg on day 1 (8 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 8 mg at bedtime) or 24 mg as a single or in 2-3 divided doses upon initiation (regardless of time of day); 20 mg on day 2 (4 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 8 mg at bedtime); 16 mg on day 3 (4 mg before breakfast, 4 mg after lunch, 4 mg after...
... Show moreChild Dose
Oral
Anti-inflammatory or immunosuppressive
Child: 0.5-1.7 mg/kg daily or 5-25 mg/m2 daily in divided doses 6-12 hrly.
Usual dosing range, 0.117-1.66 mg/kg/day PO divided q6-8hr
Contraindication
Systemic fungal infections and known hypersensitivity to components.
Mode of Action
Methylprednisolone is a synthetic corticosteroid with mainly glucocorticoid activity and minimal mineralocorticoid properties. It decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Precaution
Patient w/ heart failure, HTN, DM, GI disease (e.g. diverticulitis, intestinal anastomoses, peptic ulcer, ulcerative colitis), multiple sclerosis, myasthenia gravis, acute MI, cataracts, glaucoma, osteoporosis, history of seizure disorder, thyroid disease. Avoid abrupt withdrawal. Renal and hepatic impairment (including cirrhosis). Childn. Pregnancy and lactation. Monitoring Parameters Monitor BP, blood glucose, electrolytes, growth in childn.
Lactation: Drug enters milk; use with caution
Side Effect
Adrenal suppression, anaphylactoid reactions, immunosuppression, acute myopathy, Kaposi's sarcoma, psychiatric disturbances (e.g. depression, euphoria, insomnia, mood swings, personality changes), increased susceptibility and severity of infections, impaired healing, HTN, Na and fluid retention, CV collapse (high dose), peptic ulcer, cataract subcapsular, skin atrophy, acne, muscular weakness, growth retardation, decreased blood K; dermal/subdermal skin depression at inj site. Topical: Itching, burning erythema, vesiculation; rarely, folliculitis, hypertrichosis, perioral dermatitis, skin discolouration, allergic skin reactions.
Interaction
Loss of corticosteroid-induced adrenal suppression w/ aminoglutethimide. Risk of hypokalaemia w/ K-depleting agents (e.g. amphotericin B, diuretics). Decreased clearance w/ macrolide antibiotics. May decrease serum levels of isoniazid. Increased clearance w/ cholestyramine. Risk of convulsions w/ ciclosporin. Increased risk of arrhythmias w/ digitalis glycosides. Decreased metabolism w/ oestrogens, including OCs. Enhanced metabolism w/ CYP3A4 inducers (e.g. rifampicin, barbiturates). Increased plasma concentrations w/ CYP3A4 inhibitors (e.g. ketoconazole, erythromycin). Risk of GI effects w/ aspirin or other NSAIDs. May increase the anticoagulant effect of warfarin. May reduce the therapeutic effect of antidiabetics. Potentially Fatal: May diminish response to live or live, attenuated...
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