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Bugesic
Beximco Pharmaceuticals Ltd.
Generic: Buprenorphine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Bugesic.
CONSULT YOUR DOCTOR
Bugesic may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Bugesic is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Bugesic may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Bugesic should be used with caution in patients with severe kidney disease. Dose adjustment of Bugesic may be needed. Please consult your doctor.
CAUTION
Bugesic should be used with caution in patients with liver disease. Dose adjustment of Bugesic may be needed. Please consult your doctor.
Use of Bugesic is not recommended in patients with serious liver disease.
Medicine Overview of Bugesic 200mcg Tablet
Introduction
Bugesic is used to treat moderate to severe pain and drug dependence/addiction to opioids. It helps to prevent withdrawal symptoms that may be caused due to withdrawal of other opioids. Bugesic is only prescribed to individuals who are at least 16 years of age or above. It may be habit forming and should be taken only as directed by your doctor. The medicine may be a part of your treatment which could include receiving social and psychological support. It can be taken with or without food. You should continue taking this medicine regularly until the doctor tells you it is...
... Show moreUses of Bugesic
- Opioid (Morphine) dependence
Side effects of Bugesic
Common
- Weakness
- Drug withdrawal syndrome
How to use Bugesic
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bugesic may be taken with or without food, but it is better to take it at a fixed time.
How Bugesic works
Bugesic is a opioid partial agonist. It prevents withdrawal symptoms in patients who stop taking opioid drugs by producing similar effects to these drugs.
Quick Tips
- Take it at the same time every day to help you remember to take it.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Use caution while driving or doing anything that requires concentration as Bugesic can cause dizziness and sleepiness.
- Avoid drinking alcohol or taking other medicines that can cause drowsiness.
- Discontinue the medicine and inform your doctor if you experience difficulty breathing.
- Do not stop taking Bugesic without talking to your doctor first as it may cause a worsening of symptoms.
- Your doctor may get regular blood tests to check for liver function while taking this medicine.
Brief Description
Indication
Pain, Anaesthesia, Opioid dependence
Administration
V Preparation
Solution: Dilute to final concentration of 15 mcg/mL in D5W, D5/NS, NS, or LR
Administer via controlled infusion device
IV/IM Administration
Administer by deep IM injection, by slow IV injection over >2 minutes, or by continuous IV infusion
Also may be given by epidural injection at concentration of 6-30 mcg/mL
Adult Dose
Adult: Sublingual Moderate to severe pain 200-400 mcg 6-8 hrly.
IV Perioperative analgesia 300-450 mcg via slow inj.
IV/IM Moderate to severe pain 300-600 mcg 6-8 hrly.
IM Anesth premed 300 mcg.
Elderly:
Moderate-to-Severe Pain
0.15 mg IV/IM q6hr; for IV, administered slowly over 2 minutes
Child Dose
Moderate-to-Severe Pain
12 years: As in adults
Contraindication
Acute alcoholism; convulsive disorders; head injuries; increased intracranial pressure; comatose patients; resp depression and obstructive airway disease; patients on established opioid agonists.
Mode of Action
Buprenorphine exerts its analgesic effect by binding to the mu-opioid receptors in the CNS. It has a longer duration of analgesic action than morphine. Its partial agonist activity gives it a low level of physical dependence. Buprenorphine and morphine show similar dose-related resp depressant effect.
Precaution
Hepatic or renal disease; pregnancy, lactation; hypothyroidism; adrenocortical insufficiency; asthma; prostatic hyperplasia; shock; hypotension; inflammatory or obstructive bowel disorders; myasthaenia gravis; infants/neonates. Reduce dose in elderly and debilitated patients. May precipitate withdrawal symptoms in narcotic addicts.
Lactation: Drug enters breast milk; use not recommended
Side Effect
>10%
Sedation (2/3 of patients)
1-10%
Dizziness,Headache,Hypotension,Hypoventilation,Miosis,Nausea,Sweating,Vertigo,Vomiting
<1%
Abdominal cramps,Amblyopia,Apnea,Blurred vision,Bradycardia,Coma,Confusion,Conjunctivitis,Constipation,Cyanosis,Depersonalization,Diplopia,Dreaming,Dry mouth,Dyspepsia,Dyspnea,Electrocardiographic (ECG) abnormalities,Euphoria,Fatigue,Flatulence,Hallucinations,Hypertension,Injection-site reactions,Malaise,Mental depression,Mydriasis,Nervousness,Paresthesia,Pruritus,Psychosis,Respiratory depression,Slurred speech,Tachycardia,Urticaria
Pregnancy Category Note
Pregnancy Data in pregnancy are limited; however, these data do not indicate an increased risk of major malformations specifically due to buprenorphine exposure; observational studies reported on congenital malformations among exposed pregnancies, but were also not designed appropriately to assess risk of congenital malformations specifically due to drug exposure Dosage adjustments of buprenorphine may be required during pregnancy, even if patient was maintained on stable dose prior to pregnancy; withdrawal signs and symptoms should be monitored closely and the dose adjusted as necessary Fetal/neonatal adverse reactions Neonatal opioid withdrawal syndrome may occur in newborn infants of mothers who are receiving...
... Show moreInteraction
Plasma-buprenorphine concentrations may be affected when co-administered with drugs that induce or inhibit cytochrome P450 isoenzyme CYP3A4. Enhanced depressant effects with other CNS depressants e.g. alcohol, anaesthetics, anxiolytics, hypnotics, TCAs and antipsychotics.
Potentially Fatal: Diazepam may produce resp and cardiac collapse.
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