Bumecard1mg

Indication

Hypertension, Heart failure, Oedema, Nephrotic syndrome

Administration

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Adult Dose

Oral Oedema Adult: 1 mg once daily. Give 2nd dose 6-8 hr later if necessary. Elderly: 0.5 mg daily. Refractory oedema Adult: Initially, 5 mg dail... View More

Contraindication

Hypersensitivity, progressive renal failure and anuria, hepatic coma, severe electrolyte depletion.

Mode of Action

Bumetanide induces diuresis by inhibiting reabsorption of water and electrolytes (sodium and chloride) in the ascending loop of Henle and proximal renal... View More

Precaution

Pregnancy, lactation; regular monitoring of serum electrolytes (especially potassium, calcium, magnesium); in case of hypokalemia, potassium supplements... View More

Side Effect

>10% Hyperuricemia (18%),Hypochloremia (15%),Hypokalemia (15%),Azotemia (11%) 1-10% Hyponatremia (9%),Hyperglycemia (7%),Increased serum creatinine... View More

Pregnancy Category Note

Pregnancy category: C Lactation: Unknown whether drug is excreted in breast milk; use with caution

Interaction

Reduced diuretic and natriuretic actions by probenecid. Indometacin blunts action of bumetanide; concurrent usage with antihypertensives may increase ri... View More