Mabthera 500500mg/10ml
Injection
Roche Bangladesh Pharmaceutical
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| Alcohol | CAUTION Caution is advised when consuming alcohol with Mabthera 500. Please consult your doctor. |
| Pregnancy | CONSULT YOUR DOCTOR Mabthera 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the devel... View More |
| Breastfeeding | SAFE IF PRESCRIBED Mabthera 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby... View More |
| Driving | CONSULT YOUR DOCTOR It is not known whether Mabthera 500 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate an... View More |
| Kidney | SAFE IF PRESCRIBED Mabthera 500 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Mabthera 500 may not be ne... View More |
| Liver | CONSULT YOUR DOCTOR There is limited information available on the use of Mabthera 500 in patients with liver disease. Please consult your doctor.
Use of Mabthera 500 is not... View More |
Introduction
Mabthera 500 is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis w... View More
Uses of Mabthera 500
- Non-Hodgkin lymphoma (NHL)
- Rheumatoid arthritis
- Blood cancer (Chronic lymphocytic leukemia)
- Granulomatosis with polyangiitis
- Microscopic polyangiitis
Side effects of Mabthera 500
- Headache
- Weakness
- Edema (swelling)
- Infection
- Hair loss
- Itching
- Chills
- Febrile neutropenia
- Decreased white blood cell count (neutrophils)
- Infusion reaction
- Increased risk of infection
- Decreased blood cells (red cells, white cells, and platelets)
How to use Mabthera 500
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Mabthera 500 works
Mabthera 500 is a monoclonal antibody. It works by targeting the unwanted activity of immune cells (B cells) in rheumatoid arthritis and certain types o... View More
What if you forget to take Mabthera 500?
If you miss a dose of Mabthera 500, please consult your doctor.
- It is given as a drip (intravenous infusion) by your doctor or nurse.
- You may be given some painkillers, antihistamine and possibly steroids before the drip to help prevent infusion reaction.
- Your doctor may get blood tests done to check for hepatitis B before treatment and to monitor your blood cells during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Inform your doctor if you have any heart rhythm problems, if you are having surgery or if you plan to get any vaccinations.
Indication
Non-Hodgkin's lymphoma; follicular lymphoma
Administration
Reconstitution: Dilute the appropriate dose w/ sodium chloride 0.9% or glucose 5% to a final concentration of between 1 and 4 mg/mL. IV Administratio... View More
Adult Dose
Intravenous Non-Hodgkin Lymphoma Recommended dose for NHL 375 mg/m² IV infusion according to the following schedules Relapsed or refractory low-g... View More
Child Dose
Safety and efficacy not established
Contraindication
Lactation. Type I hypersensitivity or anaphylactic reactions to murine proteins or component of the formulation.
Mode of Action
Rituximab is a chimeric monoclonal antibody to CD20 antigen which regulates cell cycle initiation. It binds to the antigen on the cell surface, activati... View More
Precaution
Extensive tumor burden, pulmonary tumor infiltration or pulmonary insufficiency; history of cardiac disease; effective contraception during and up to 12... View More
Side Effect
>10% NHL Angioedema (11%), hypotension (10%), Asthenia (26%), chills (33%), dizziness (10%), fever (53%), headache (19%) Pruritus (14%), rash (15%), ... View More
Interaction
Increased risk of renal toxicity w/ cisplatin. Potentially Fatal: May decrease the efficacy of vaccines and increase the risk of infections in patien... View More
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not... View More